早期胃癌患者血清TGFBI、COL10A1水平与其ESD术后复发的关系研究  

Association of serum levels of TGFBI and COL10A1 with recurrence after endoscopic submucosal dissection in patients with early gastric cancer

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作  者:薛玲[1] 王志伟[2] Xue Ling;Wang Zhiwei(Department of Oncology,Hanzhong Central Hospital,Hanzhong 723000,Shaanxi Province,China;Department of Digestive Surgery,Hanzhong Central Hospital,Hanzhong 723000,Shaanxi Province,China)

机构地区:[1]汉中市中心医院肿瘤内科,汉中723000 [2]汉中市中心医院消化外科,汉中723000

出  处:《中国基层医药》2025年第3期347-352,共6页Chinese Journal of Primary Medicine and Pharmacy

摘  要:目的探讨早期胃癌患者血清转化生长因子-β诱导蛋白(TGFBI)、Xɑ1型胶原蛋白(COL10A1)水平及其与内镜黏膜下剥离术(ESD)术后复发的关系。方法采取前瞻性研究,选择2020年3月至2023年3月汉中市中心医院收治的行ESD治疗的早期胃癌患者110例为研究对象,采用横断面研究方法,患者ESD术后随访1年,记录患者期间复发情况,并分为复发组、未复发组。患者入院时均接受血清TGFBI、COL10A1检测,统计患者基线资料。分析早期胃癌患者血清TGFBI、COL10A1水平与ESD术后复发的剂量反应关系。结果随访术后1年,110例早期胃癌患者ESD术后复发17例,复发率为15.45%,复发组肿瘤最长径[(2.37±0.41)cm]长于未复发组[(1.85±0.34)cm];复发组患者血清TGFBI、COL10A1水平[(27.85±6.27)μg/L、(7.03±1.05)μg/L]均高于未复发组[(19.28±4.15)μg/L、(6.14±0.77)μg/L],临床分期为Ⅱa~Ⅱb、浸润深度为黏膜下层患者[52.94%(9/17)、70.59%(12/17)]占比高于未复发组[24.73%(23/93)、43.01%(40/93)](t=5.61、7.17、4.12,χ^(2)=4.26、4.38,均P<0.05);二元logistics回归分析结果显示,早期胃癌患者肿瘤最长径长、血清TGFBI、COL10A1高表达是ESD术后复发的危险因素(OR=65.341、1.401、2.855,均P<0.05);受试者工作特征(ROC)曲线分析显示,早期胃癌患者血清TGFBI、COL10A1及联合预测ESD术后复发的曲线下面积(AUC)分别为0.869、0.800、0.954;早期胃癌患者血清TGFBI、COL10A1与ESD术后复发的关联强度均呈线性剂量反应关系(均P<0.05),特别当血清TGFBI>22.29μg/L、COL10A1>6.95μg/L时,早期胃癌患者ESD术后复发风险随血清TGFBI、COL10A1水平升高而升高。结论早期胃癌患者血清TGFBI、COL10A1水平与ESD术后复发密切相关,两者水平越高患者复发风险越高。Objective To investigate the association between serum levels of transforming growth factor beta-induced protein(TGFBI)and type X alpha1 collagen(COL10A1)in patients with early gastric cancer and the recurrence of cancer after endoscopic submucosal dissection(ESD).Methods A prospective study was conducted involving 110 patients with early gastric cancer who underwent ESD at the Hanzhong Central Hospital from March 2020 to March 2023.This study used a cross-sectional study design,with patients followed up for 1 year post-ESD to assess recurrence.Patients were categorized into the recurrence group and the non-recurrence group.Upon admission,all patients underwent serum testing for TGFBI and COL10A1,and baseline data were collected.The dose-response relationship between serum levels of TGFBI and COL10A1 and the recurrence of cancer after ESD was analyzed.Results After 1 year of follow-up,recurrence was observed in 17 out of 110 patients with early gastric cancer who underwent ESD,resulting in a recurrence rate of 15.45%.In the recurrent group,the longest diameter of the tumors[(2.37±0.41)cm]was significantly longer than that in the non-recurrent group[(1.85±0.34)cm].Additionally,serum levels of TGFBI and COL10A1 in the recurrence group were(27.85±6.27)μg/L and(7.03±1.05)μg/L,respectively,which were significantly higher than those in the non-recurrence group[(19.28±4.15)μg/L,(6.14±0.77)μg/L].The proportion of patients with clinical stagesⅡa-b and submucosal infiltration depth was significantly greater in the recurrence group[52.94%(9/17),70.59%(12/17)]than in the non-recurrence group[24.73%(23/93),43.01%(40/93)]in the non-recurrent group.All observed differences were statistically significant(t=5.61,7.17,4.12,χ^(2)=4.26,4.38,all P<0.05).The results of the binary logistic regression analysis showed that the longest tumor diameter,high serum levels of TGFBI and COL10A1 expression were risk factors for recurrence after ESD in patients with early gastric cancer(OR=65.341,1.401,2.855,all P<0.05).The results o

关 键 词:胃肿瘤 胃黏膜 内窥镜检查 胃肠道 转化生长因子Β 复发 回归分析 ROC曲线 

分 类 号:R73[医药卫生—肿瘤]

 

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