神经系统在肿瘤发生发展中的作用  

Role of the nervous system in tumor occurrence and development

作　　者：董良伊 陈小兵[2] 王赛琪 程铭震 任永静 王宇航 胡伟[1] Dong Liangyi;Chen Xiaobing;Wang Saiqi;Cheng Mingzhen;Ren Yongjing;Wang Yuhang;Hu Wei(Department of Thoracic Surgery,First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Gastroenterology,He'nan Provincial Cancer Hospital,Zhengzhou 450008,China;Department of Clinical Medicine,School of Medicine,Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院胸外科,郑州450052 [2]河南省肿瘤医院消化内科,郑州450008 [3]郑州大学医学院临床医学系,郑州450052

出　　处：《中华神经医学杂志》2025年第3期310-316,共7页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金青年项目(82103560);河南省自然科学基金重点科学基金项目(232300421119)。

摘　　要：神经系统不仅影响肿瘤的增殖、转移、血管生成等核心过程,还与肿瘤相关疼痛及恶病质等症状密切相关。同时,肿瘤细胞可以借助神经路径侵入邻近组织,发生神经周围浸润,促进肿瘤的发展。本文从肿瘤的神经周围浸润,神经营养因子、自主神经和感觉神经、神经免疫系统对肿瘤的影响等角度出发,围绕神经系统在肿瘤发生发展中的作用研究进展进行综述,以期为肿瘤的治疗提供新的视角和方法。The nervous system not only affects the core processes of tumors such as proliferation,metastasis and angiogenesis,but is also closely related to symptoms such as tumor-related pain and cachexia.Meanwhile,tumor cells can invade adjacent tissues through nerve pathways to induce perineural invasion,which promotes tumor development.This article reviews the research progress in role of the nervous system in tumor occurrence and development from perspectives of tumor perineural invasion,neurotrophic factors,autonomic and sensory nerves,and influence of the neuroimmune system in tumors,in order to provide new perspective and method for tumor treatment.

关 键 词：神经系统 肿瘤 自主神经 神经周围浸润 免疫功能 雪旺细胞 细胞外囊泡 

分 类 号：R730.2[医药卫生—肿瘤]