RNA modifications:emerging players in the regulation of reproduction and development  

作　　者：Junfei Wen Qifan Zhu Yong Liu Lan-Tao Gou 

机构地区：[1]Key Laboratory of RNA Innovation,Science and Engineering,Shanghai Key Laboratory of Molecular Andrology,CAS Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,Shanghai 200031,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]Anhui Province Key Laboratory of Embryo Development and Reproductive Regulation,School of Biological and Food Engineering,Fuyang Normal University,Fuyang 236037,China

出　　处：《Acta Biochimica et Biophysica Sinica》2025年第1期33-58,共26页生物化学与生物物理学报(英文版)

基　　金：supported by the grants from the National Key R&D Program of China(Nos.2021YFC2700200 and 2022YFC2702600);the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0570000);the National Natural Science Foundation of China(Nos.32170815 and 32300459);the Biological and Medical Sciences of Applied Summit Nurturing Disciplines in Anhui Province(Anhui Education Secretary Department[2023]13).

摘　　要：The intricate world of RNA modifications,collectively termed the epitranscriptome,covers over 170 identified modifications and impacts RNA metabolism and,consequently,almost all biological processes.In this review,we focus on the regulatory roles and biological functions of a panel of dominant RNA modifications(including m^(6)A,m^(5)C,Ψ,ac^(4)C,m^(1)A,and m^(7)G)on three RNA types—mRNA,tRNA,and rRNA—in mammalian development,particularly in the context of reproduction as well as embryonic development.We discuss in detail how those modifications,along with their regulatory proteins,affect RNA processing,structure,localization,stability,and translation efficiency.We also highlight the associations among dysfunctions in RNA modification-related proteins,abnormal modification deposition and various diseases,emphasizing the roles of RNA modifications in critical developmental processes such as stem cell self-renewal and cell fate transition.Elucidating the molecular mechanisms by which RNA modifications influence diverse developmental processes holds promise for developing innovative strategies to manage developmental disorders.Finally,we outline several unexplored areas in the field of RNA modification that warrant further investigation.

关 键 词：RNA modification REPRODUCTION epitranscriptomic mammalian development developmental disease 

分 类 号：R73[医药卫生—肿瘤]