西洛他唑联合阿司匹林治疗急性脑梗死的效果及对血液流变学指标的影响  

Efficacy of cilostazol combined with aspirin in the treatment of acute cerebral infarction and its impact on hemorheological indices

作　　者：张国洲 ZHANG Guozhou(Department of Pharmacy,Zhongshan Hospital,the First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangdong,Zhongshan 528401,China)

机构地区：[1]广州中医药大学第一附属医院中山医院药剂科,广东中山528401

出　　处：《中国医药科学》2025年第5期128-131,140,共5页China Medicine And Pharmacy

摘　　要：目的探讨西洛他唑联合阿司匹林治疗急性脑梗死的效果及对血液流变学指标的影响。方法选取广州中医药大学第一附属医院中山医院2021年1月至2022年6月收治的96例急性脑梗死患者,按照随机数表法分为两组。A组(48例)予以阿司匹林治疗,B组(48例)予以西洛他唑联合阿司匹林治疗,两组均治疗2周。比较两组的神经功能、血液流变学指标、炎症因子水平(白细胞介素-6、肿瘤坏死因子-α)、临床疗效、不良反应、预后情况。结果两组治疗后的美国国立卫生研究院卒中量表(NIHSS)评分均较治疗前降低,差异有统计学意义(P<0.05);B组治疗后的NIHSS评分低于A组,差异有统计学意义(P<<0.05)。两组治疗后的高切全血黏度、低切全血黏度、血浆黏度、纤维蛋白原均较治疗前降低,差异有统计学意义(P<0.05);B组治疗后的高切全血黏度、低切全血黏度、血浆黏度、纤维蛋白原低于A组,差异有统计学意义(P<0.05)。两组治疗后的白细胞介素-6、肿瘤坏死因子-α均较治疗前降低,差异有统计学意义(P<<0.05);B组治疗后的白细胞介素-6、肿瘤坏死因子-α低于A组,差异有统计学意义(P<0.05)。B组的临床总有效率高于A组,差异有统计学意义(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。B组的不良预后总发生率低于A组,差异有统计学意义(P<0.05)。结论西洛他唑联合阿司匹林治疗急性脑梗死的效果较好,可改善神经功能、血液流变学指标,降低炎症因子水平,改善患者预后,值得推广。Objective To investigate the efficacy of cilostazol combined with aspirin in the treatment of acute cerebral infarction and its impact on hemorheological indices.Methods A total of 96 patients with acute cerebral infarction admitted to and treated in Zhongshan Hospital,the First Affiliated Hospital of Guangzhou University of Chinese Medicine from January 2021 to June 2022 were selected and divided into Group A(n=48)and Group B(n=48)according to the random number table method.Group A was treated with aspirin,while Group B was treated with cilostazol combined with aspirin.Both groups were treated for 2 weeks.The neurological function,hemorheological indices,levels of inflammatory factors(IL-6,TNF-α),clinical efficacy,adverse reactions(ADRs)and prognosis of the two groups were compared.Results After treatment,the scores of National Institutes of Health Stroke Scale(NIHSS)all decreased in both groups,with statistically significant difference(P<0.05).After treatment,the NIHSS score of Group B was lower than that of Group A,with statistically significant difference(P<0.05).After treatment,the high-shear whole blood viscosity,low-shear whole blood viscosity,plasma viscosity and fibrinogen in the two groups all decreased,with statistically significant differences(P<0.05).After treatment,the high-shear whole blood viscosity,low-shear whole blood viscosity,plasma viscosity and fibrinogen in Group B were lower than those in Group A,with statistically significant differences(P<0.05).After treatment,the levels of IL-6 and TNF-αin the two groups all decreased,with statistically significant differences(P<0.05).After treatment,the levels of IL-6 and TNF-αin Group B were lower than those in Group A,with statistically significant differences(P<0.05).The total rate of clinical efficacy in Group B was higher than that in Group A,with statistically significant difference(P<0.05).There was no statistically significant difference in total incidence of ADRs between Group A and Group B(P>0.05).The total incidence of adverse prognosis

关 键 词：西洛他唑 阿司匹林 急性脑梗死 疗效 血液流变学指标 

分 类 号：R743.3[医药卫生—神经病学与精神病学]