丁苯酞注射液治疗大脑中动脉缺血性脑卒中患者的效果分析  

Effect Analysis of Butylphthalide Injection on Patients with Middle Cerebral Artery Ischemic Stroke

作　　者：宋和雁 SONG Heyan(Department of Neurology,Yishui County Second People’s Hospital,Linyi 276000,China)

机构地区：[1]山东省沂水县第二人民医院神经内科,山东临沂276000

出　　处：《中国伤残医学》2025年第5期46-50,共5页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探讨丁苯酞注射液治疗大脑中动脉(MCA)缺血性脑卒中患者的效果。方法:回顾性分析2022年5月—2024年5月沂水县第二人民医院收治的90例MCA缺血性脑卒中患者资料,按治疗方法的不同将其分为对照组及研究组,各45例。对照组采用常规治疗,研究组在对照组基础上采用丁苯酞注射液治疗。两组均治疗4周。比较两组临床疗效、神经功能、脑梗死面积、血清炎性因子、大脑血流指标及不良反应发生情况。结果:研究组的治疗总有效率为91.11%,高于对照组的75.56%,差异有统计学意义(P<0.05)。治疗后,研究组的美国国立卫生研究院卒中量表评分低于对照组,脑梗死面积小于对照组,差异均有统计学意义(P<0.05)。治疗后,研究组的白细胞介素-6、丙二醛、肿瘤坏死因子-α水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后,研究组的大脑前、中、后动脉血流速度均快于对照组,差异均有统计学意义(P<0.05)。研究组的不良反应发生率为13.33%,与对照组的6.67%相比较,差异无统计学意义(P>0.05)。结论:MCA缺血性脑卒中患者采用丁苯酞注射液治疗的效果显著,可有效改善血液流动速度,降低血清炎性因子水平,减小脑梗死面积,促进神经功能恢复,且用药安全。Objective:To investigate the effect of Butylphthalide Injection in the treatment of middle cerebral artery(MCA)ischemic stroke.Methods:Data of 90 MCA ischemic stroke patients admitted to Yishui County Second People’s Hospital from May 2022 to May 2024 were retrospectively analysed,and were divided into a control group and a study group according to different treatment methods,with 45 cases in each group.The control group was treated with conventional treatment,and the study group was treated with Butylphthalide Injection on the basis of the control group.Both groups were treated 4 weekds.The clinical efficacy,neurological function,infarction area,serum inflammatory factor,cerebral blood flow indexes and the occurrence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 91.11%,which was higher than 75.56%of the control group,the difference was statistically significant(P<0.05).After treatment,the National Institute of Health Stroke Scale score of the study group was lower than that of the control group,and the cerebral infarction size was smaller than that of the control group,the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-6,malondialdehyde and tumor necrosis factor-αin the study group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the blood flow velocities of anterior,middle and posterior cerebral artery of the study group were faster than those of the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the study group was 13.33%,compared with 6.67%in the control group,there was no statistical significance(P>0.05).Conclusion:The treatment effect of Butylphthalide Injection in MCA ischemic stroke patients is significant,which can effectively improve the blood flow velocity,reduce the level of serum inflammatory factors,reduce the cerebellar infarction area,promote the recovery

关 键 词：大脑中动脉缺血性脑卒中 丁苯酞注射液 血清炎性因子 神经功能 脑梗死面积 大脑血流指标 

分 类 号：R743.3[医药卫生—神经病学与精神病学]