血清鳞状细胞癌抗原联合糖类抗原125术前预测宫颈鳞癌患者淋巴结转移的价值分析  

Value Analysis of Serum Squamous Cell Carcinoma Antigen Combined with Carbohydrate Antigen 125 for Preoperative Prediction of Lymph Node Metastasis in Patient with Cervical Squamous Cell Carcinoma

作　　者：汪来美 WANG Laimei(Department of Pathology,Wannian People’s Hospital,Shangrao 334000,China)

机构地区：[1]江西省万年县人民医院病理科,江西上饶334000

出　　处：《中国伤残医学》2025年第5期91-94,118,共5页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:分析术前血清鳞状细胞癌抗原(SCC-Ag)联合糖类抗原125(CA125)检测对宫颈鳞癌患者淋巴结转移的预测价值。方法:回顾性分析万年县人民医院2021年1月—2023年9月收治的120例经病理诊断确诊为宫颈鳞状细胞癌的患者资料,所有患者均接受根治性子宫切除术及盆腔淋巴结清扫术加/不加腹主动脉旁淋巴结清扫术,根据术后病理淋巴结情况分为淋巴结转移组(n=42)与非淋巴结转移组(n=78)。收集两组术前一般资料和血清SCC-Ag、CA125并对比。绘制受试者操作特征曲线(ROC)分析术前血清SCC-Ag、CA125预测宫颈鳞患者淋巴结转移的预测价值。结果:淋巴结转移组的SCC-Ag、CA125低于非淋巴结转移组,绝经情况较非淋巴结转移组差,产次少于非淋巴结转移组,差异均有统计学意义(P<0.05)。Logistic回归分析结果显示,已绝经、SCC-Ag、CA125水平高是宫颈鳞癌患者淋巴结转移的危险因素(P<0.05)。ROC曲线结果显示血清SCC-Ag、CA125单独及联合预测宫颈鳞癌患者淋巴结转移的曲线下面积分别为0.750、0.782、0.855,联合预测的曲线下面积高于单独预测。结论:术前血清SCC-Ag联合CA125预测宫颈鳞癌患者淋巴结转移具有较高的价值,临床可应用参考。Objective:To evaluate the predictive value of serum squamous cell carcinoma antigen(SCC-Ag)combined with carbohydrate antigen 125(CA125)detction in lymph node metastasis in patients with cervical squamous cell carcinoma.Methods:The data of 120 patients diagnosed with cervical squamous cell carcinoma by pathological diagnosis admitted to Wanian People’s Hospital from January 2021 to September 2023 were retrospectively analyzed.All patients received radical hysterectomy and pelvic lymph node dissection with or without paraaortic lymph node dissection.According to postoperative pathological lymph node,the patients were divided into the lymph node metastasis group(n=42)and the non-lymph node metastasis group(n=78).Preoperative general data and serum SCC-Ag and CA125 levels were collected and compared between the two groups.Receiver operating characteristic(ROC)curves were drawn to analyze the values of preoperative serum SCC-Ag and CA125 in predicting lymph node metastasis in patient with cervical squamous cell carcinoma.Results:SCC-Ag and CA125 in lymph node metastasis group were lower than those in non-lymph node metastasis group,menopause was worse than that in non-lymph node metastasis group,and the birth times were lower than that in non-lymph node metastasis group,the differences were statistically significant(P<0.05).Logistic regression analysis showed that menopause,high levels of SCC-Ag and CA125 were risk factors for lymph node metastasis in patients with cervical squamous cell carcinoma(P<0.05).ROC curve results showed that the areas under the curve of serum SCC-Ag and CA125 alone and combined to predict lymph node metastasis in patients with cervical squamous cell carcinoma were 0.750,0.782 and 0.855,respectively,and the area under the curve of combined prediction was higher than those of single prediction.Conclusion:Preoperative serum SCC-Ag combined with CA125 has high value in predicting lymph node metastasis in patients with cervical squamous cell carcinoma,it can be used for clinical reference.

关 键 词：宫颈鳞癌 鳞状细胞癌抗原 糖类抗原125 淋巴结转移 

分 类 号：R737.33[医药卫生—肿瘤]