胃癌患者MARCKS、UHRF1、HIF-1α、CDK12的表达与临床病理特征的关系  

Relationship between the Expression of MARCKS,UHRF1,HIF-1α,CDK12 and Clinicopathological Characteristics in Patients with Gastric Cancer

作　　者：牛忠杰 NIU Zhongjie(Department of Pathology,Jiyang District People’s Hospital,Jinan 250000,China)

机构地区：[1]山东省济南市济阳区人民医院病理科,山东济南250000

出　　处：《中国伤残医学》2025年第7期91-95,共5页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探讨胃癌患者豆蔻酰化的富含丙氨酸的蛋白激酶C底物(MARCKS)、泛素样含PHD和环指域蛋白1(UHRF1)、缺氧诱导因子-1α(HIF-1α)、细胞周期蛋白依赖性激酶12(CDK12)的表达及其与临床病理特征的关系。方法:选取2021年1月—2024年5月济南市济阳区人民医院收治的80例胃癌患者为研究对象,采集患者病理组织及癌旁正常组织。比较病理组织及癌旁正常组织MARCKS、UHRF1、HIF-1α、CDK12的表达情况,分析MARCKS、UHRF1、HIF-1α、CDK12表达与病理特征的关系。结果:病理组织MARCKS、UHRF1、HIF-1α、CDK12阳性表达率均高于癌旁正常组织,差异均有统计学意义(P<0.05)。肿瘤TNM分期Ⅲ期、有淋巴结转移、分化程度低分化、肿瘤直径≥5cm患者MARCKS、UHRF1、HIF-1α、CDK12阳性表达率均高于肿瘤TNM分期Ⅰ~Ⅱ期、无淋巴结转移、分化程度高中分化、肿瘤直径<5cm患者,差异均有统计学意义(P<0.05)。结论:MARCKS、UHRF1、HIF-1α、CDK12在胃癌组织内存在较高表达,且与肿瘤分期、淋巴结转移关系密切,可作为指导临床治疗的重要标志物。Objective:To investigate the relationship between the expression of myristoylated alanine-rich C kinase substrate(MARCKS),ubiquitin like with PHD and ring finger domains1(UHRF1),hypoxia inducible factor-1α(HIF-1α),Cyclin dependent kinase 12(CDK12)and clinicopathological characteristics in patients with gastric cancer.Methods:A totle of 80 patients with gastric cancer admitted to the Jiyang District People’s Hospital from January 2021 to May 2024 were selected as the study objects,the pathological tissues and normal tissues adjacent to cancer from patients were collecedt.The expression of MARCKS,UHRF1,HIF-1α,and CDK12 were compared between pathological tissues and normal tissues adjacent to cancer.The relationship between MARCKS,UHRF1,HIF-1α,CDK12 expression and clinicopathological characteristics were analyzed.Results:The positive expression rates of MARCKS,UHRF1,HIF-1α,and CDK12 in pathological tissues were higher than those in normal tissues adjacent to cancer,with statistical differences(P<0.05).The positive expression rates of MARCKS,UHRF1,HIF-1α,and CDK12 in patients with TNM stageⅢ,lymph node metastasis,low differentiation,tumor diameter≥5 cm were higher than those in patients with TNM stage I~II,no lymph node metastasis,high differentiation,and tumor diameter<5 cm,with statistical differences(P<0.05).Conclusion:MARCKS,UHRF1,HIF-1α,and CDK12 are highly expressed in gastric cancer tissues and closely related to tumor staging and lymph node metastasis.they can serve as important biomarkers to guide clinical treatment.

关 键 词：胃癌 豆蔻酰化的富含丙氨酸的蛋白激酶C底物 类泛素样含环指域蛋白1 细胞周期蛋白依赖性激酶12 缺氧诱导因子-1Α 临床病理特征 

分 类 号：R735.2[医药卫生—肿瘤]