卵巢癌患者血清癌胚抗原、糖类抗原125、人附睾蛋白4水平与淋巴结转移、预后的关系分析  

Serum carcinoembryonic antigen,carbohydrate antigen 125 and human epididymis protein 4 levels and their relationship with lymph node metastasis and prognosis in the patients with ovarian cancer

作　　者：白金伟 李宁 王茜 BAI Jinwei;LI Ning;WANG Qian(Department of Laboratory Medicine,Kaifeng Central Hospital,Kaifeng 475000,China;Department of Oncology,Kaifeng Central Hospital,Kaifeng 475000,China)

机构地区：[1]开封市中心医院检验科,河南开封475000 [2]开封市中心医院肿瘤科,河南开封475000

出　　处：《肿瘤基础与临床》2025年第1期10-13,共4页journal of basic and clinical oncology

基　　金：开封市科技发展计划项目(2203)。

摘　　要：目的分析卵巢癌患者血清癌胚抗原(CEA)、糖类抗原125(CA125)、人附睾蛋白4(HE4)水平及其与淋巴结转移、预后的关系。方法回顾性分析2020年6月至2021年6月期间在开封市中心医院接受治疗的卵巢癌患者106例患者为卵巢癌组,另选取同期106例女性健康体检正常者为健康对照组,并对卵巢癌患者随访3年,根据预后情况分为死亡组、存活组。比较卵巢癌组与健康对照组血清CEA、CA125、HE4水平;分析血清CEA、CA125、HE4水平与淋巴结转移的关系;用多因素COX回归分析卵巢癌患者预后的影响因素。结果卵巢癌组血清CEA、CA125、HE4水平均高于健康对照组(t=33.791,P<0.001;t=58.746,P<0.001;t=50.168,P<0.001)。卵巢癌淋巴结转移淋巴结转移组血清CEA、CA125、HE4水平均高于未转移组(t=4.604,P<0.001;t=3.728,P<0.001;t=5.081,P<0.001)。卵巢癌死亡组血清CEA、CA125、HE4水平均高于存活组(t=7.232,P<0.001;t=5.532,P<0.001;t=8.957,P<0.001)。卵巢癌死亡组与存活组FIGO分期、淋巴结转移比较差异有统计学意义(χ^(2)=9.349,P=0.002;χ^(2)=9.127,P=0.003)。CEA、CA125、HE4、FIGO分期、淋巴结转移均是影响卵巢癌患者预后生存的独立危险因素。结论CEA、CA125、HE4在卵巢癌患者血清中呈高表达,与患者淋巴结转移、预后关系密切。Objective To analyze the serum levels of carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),human epididymis protein 4(HE4)and their relationship with lymph node metastasis and prognosis in patients with ovarian cancer.Methods The 106 patients with ovarian cancer received treatment in Kaifeng Central Hospital from June 2020 to June 2021 were retrospectively included as the ovarian cancer group,and 106 female healthy subjects during the same period were selected as the healthy control group.The patients in the ovarian cancer group were followed up for 3 years and divided into the death group and the survival group according to the prognosis.Serum CEA,CA125 and HE4 levels were compared between the ovarian cancer group and the healthy control group.Clinical data of patients with ovarian cancer were collected to analyze the relationship between serum CEA,CA125,HE4 levels and lymph node metastasis.Multivariate COX regression was used to analyze the factors affecting prognosis and survival of ovarian cancer patients.Results The serum levels of CEA,CA125 and HE4 in the ovarian cancer group were higher than those in the healthy control group(t=33.791,P<0.001;t=58.746,P<0.001;t=50.168,P<0.001).The serum levels of CEA,CA125 and HE4 in the lymph node metastasis group of ovarian cancer were higher than those in the non-metastatic group(t=4.604,P<0.001;t=3.728,P<0.001;t=5.081,P<0.001).The serum levels of CEA,CA125 and HE4 in the ovarian cancer death group were higher than those in the survival group(t=7.232,P<0.001;t=5.532,P<0.001;t=8.957,P<0.001).There were significant differences in the FIGO staging and lymph node metastasis between the ovarian cancer death group and the survival group(t=9.349,P=0.002;t=9.127,P=0.003).Cox regression analysis results indicated that CEA,CA125,HE4,FIGO staging and lymph node metastasis were independent risk factors affecting the prognosis and survival of ovarian cancer patients.Conclusion CEA,CA125 and HE4 are highly expressed in serum of patients with ovarian cancer,which is closel

关 键 词：卵巢癌 癌胚抗原 糖类抗原125 人附睾蛋白4 淋巴结转移 预后 

分 类 号：R737.31[医药卫生—肿瘤]