小牛血清去蛋白注射液治疗脑卒中后认知功能障碍患者的效果分析  

Analysis of the Treatment Effect of Deproteinized Calf Serum Injection on Patients with Post-Stroke Cognitive Impairment

作　　者：李爱华 孟宪举 杨东锋 LI Aihua;MENG Xianju;YANG Dongfeng(Department of Neurology,Ninghe District Hospital of Tianjin,Tianjin 300000,China)

机构地区：[1]天津市宁河区医院神经内科,天津300000

出　　处：《中国伤残医学》2025年第6期89-92,共4页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:分析小牛血清去蛋白注射液(DCSI)对脑卒中后认知功能障碍(PSCI)患者的治疗效果。方法:选取2021年8月-2024年8月天津市宁河区医院收治的80例PSCI患者为研究对象,应用简单随机法将其分为对照组与研究组,各40例。对照组采用常规疗法与早期康复锻炼治疗,研究组在对照组基础上联合DCSI治疗,两组均治疗4周。对比两组临床疗效、神经炎症指标、认知功能、日常生活能力、智力水平。结果:研究组治疗总有效率90.00%,高于对照组的72.50%,差异有统计学意义(P<0.05)。治疗后,两组血清高迁移率族蛋白B1、S100A12蛋白水平均低于治疗前,且研究组均低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组蒙特利尔认知评估量表、日常生活活动能力量表、简易智能精神状态检查量表评分均高于治疗前,且研究组均高于对照组,差异均有统计学意义(P<0.05)。结论:PSCI患者采取DCSI可提升治疗效果,减轻神经炎性反应,从而进一步提升其日常生活能力,改善患者智力水平与认知功能。。Objective:To analyze the treatment effect of Deproteinised Calf serum Injection(DCSI)on patients with post-stroke cognitive impairment(PSCI).Methods:A total of 80 patients with PSCI admitted to Ninghe District Hospital of Tianjin from August 2021 to August 2024 were selected as the study objects,and were divided into a control group and a study group,with 40 cases in each group by simple randomization method.The control group was treated with conventional therapy and early rehabilitation exercise,while the study group was treated with DCSI on the basis of the control group,and both groups were treated for 4 weeks.The clinical efficacy,neuroinflammatory index,cognitive function,daily living ability and intelligence level of the two groups were compared.Results:The total effective rate of the study group was 90.00%,which was higher than 72.50%of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of serum high mobility group protein B1 and S100A12 protein in both groups were lower than those of before treatment,and the study group were lower than the control group,the differences were statistically significant(P<0.05).After treatment,the scores of Montreal Cognitive Assessment Scale,Activity of Daily Living Scale and Mini-Mental State Examination Scale in both groups were higher than before treatment,and the study group were higher than the control group,with statistical significance(P<0.05).Conclusion:DCSI in treatment for PSCI patients can improve the therapeutic effect,reduce the neuroinflammatory response,further improve their daily living ability,improve the intelligence level and cognitive function of patients.

关 键 词：脑卒中 认知功能障碍 小牛血清去蛋白注射液 高迁移率族蛋白B1 S100A12蛋白 日常生活能力 

分 类 号：R749[医药卫生—神经病学与精神病学]