IL-1βCOX-2 NO水平与卵圆孔未闭相关偏头痛患者术后缓解的关系分析  

Analysis of the Relationship Between IL-1βCOX-2 and NO Levels and Postoperative Remission in Patients with Patent Foramen Ovale-Related Migraine

作　　者：梁立龙 熊凌杰 LIANG Lilong;XIONG Lingjie(The Second People's Hospital of Hefei,Anhui Hefei 230011,China)

机构地区：[1]安徽省合肥市第二人民医院,安徽合肥230011

出　　处：《河北医学》2025年第3期486-490,共5页Hebei Medicine

基　　金：2019年安徽省重点研究与开发计划项目,(编号:201904b11020032)。

摘　　要：目的:分析白细胞介素1β(IL-1β)、环氧合酶2(COX-2)、一氧化氮(NO)水平与卵圆孔未闭相关偏头痛患者术后缓解的关系。方法:以2020年5月至2023年5月于本院行介入封堵术的105例卵圆孔未闭相关偏头痛患者为研究对象,术后3d测定血清IL-1β、COX-2、NO水平,术后随访1个月,依据其症状是否缓解将其分为缓解组(n=65)和未缓解组(n=40)。以受试者特征工作曲线(ROC)分析血清IL-1β、COX-2、NO水平对患者术后缓解的预测价值。结果:未缓解组的血清IL-1β、COX-2、NO水平高于缓解组(P<0.05)。ROC曲线显示,血清IL-1β、COX-2、NO水平联合预测术后缓解的曲线下面积(AUC)为0.895,灵敏度为85.00%,特异性为87.69%,联合预测效能优于各指标单独预测(P<0.05)。结论:血清IL-1β、COX-2、NO水平与卵圆孔未闭相关偏头痛患者术后缓解密切相关,通过术后早期测定血清IL-1β、COX-2、NO水平,可为患者的术后缓解提供一定的预测价值。Objective:To analyze the relationship between serum levels of interleukin-1β(IL-1β),cyclooxygenase-2(COX-2),and nitric oxide(NO)and postoperative remission in patients with patent foramen ovale(PFO)-related migraine.Methods:A total of 105 patients with PFO-related migraine who underwent interventional occlusion at our hospital from May 2020 to May 2023 were included in the study.Serum levels of IL-1β,COX-2,and NO were measured 3 days after surgery.Patients were followed up for 1 month postoperatively and divided into a remission group(n=65)and a non-remission group(n=40)based on symptom relief.The predictive value of serum IL-1β,COX-2,and NO levels for postoperative remission was evaluated using receiver operating characteristic(ROC)curve analysis.Results:Serum levels of IL-1β,COX-2,and NO were significantly higher in the non-remission group compared to the remission group(P<0.05).ROC curve analysis revealed that the combination of serum IL-1β,COX-2,and NO levels had an area under the curve(AUC)of 0.895,with a sensitivity of 85.00%and a specificity of 87.69%for predicting postoperative remission.The combined predictive efficiency was superior to that of each individual indicator(P<0.05).Conclusion:Serum levels of IL-1β,COX-2,and NO are closely associated with postoperative remission in patients with PFO-related migraine.Early postoperative measurement of these biomarkers may provide valuable predictive insights into patient outcomes.

关 键 词：卵圆孔未闭相关偏头痛 术后缓解 白细胞介素1Β 环氧合酶2 一氧化氮 

分 类 号：R73[医药卫生—肿瘤]