血必净联合生长抑素治疗重症急性胰腺炎患者的效果  

Effects of Xuebijing combined with Somatostatin in treatment of patients with severe acute pancreatitis

作　　者：徐慧 杨晓庆 XU Hui;YANG Xiaoqing(Department of Gastroenterology of Zhumadian Hospital of Traditional Chinese Medicine,Zhumadian 463000 Henan,China)

机构地区：[1]驻马店市中医院脾胃消化科,河南驻马店463000

出　　处：《中国民康医学》2025年第7期134-137,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察血必净联合生长抑素治疗重症急性胰腺炎(SAP)患者的效果。方法:回顾性分析2020年7月至2022年7月该院收治的76例SAP患者的临床资料,按照治疗方法不同将其分为对照组(n=34)与观察组(n=42)。对照组采用生长抑素治疗,观察组在对照组基础上联合血必净治疗。比较两组临床疗效,治疗前后T细胞亚群指标(CD3^(+)、CD4^(+)、CD8^(+))水平、血清淀粉酶(AMS)水平、脂肪酶水平、炎性因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平,以及不良反应发生率。结果:观察组治疗总有效率为95.24%(40/42),高于对照组的76.47%(26/34),差异有统计意义(P<0.05);治疗后,两组CD3^(+)、CD4^(+)水平均高于治疗前,且观察组高于对照组,两组CD8^(+)水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组AMS、脂肪酶水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组IL-6、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:血必净联合生长抑素治疗SAP患者可提高治疗总有效率,改善T细胞亚群指标水平,以及降低血清AMS、脂肪酶和炎性因子水平,效果优于单纯生长抑素治疗。Objective:To observe effects of Xuebijing combined with Somatostatin in treatment of patients with severe acute pancreatitis(SAP).Methods:The clinical data of 76 patients with SAP in this hospital from July 2020 to July 2022 were retrospectively analyzed.According to different treatment methods,they were divided into control group(n=34)and observation group(n=42).The control group was treated with Somatostatin,while the observation group was treated with Xuebijing on the basis of that of the control group.The clinical efficacy,the levels of T cell subsets(CD3^(+),CD4^(+),CD8^(+)),serum amylase(AMS),lipase,and inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.24%(40/42),which was higher than 76.47%(26/34)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of CD3^(+)and CD4^(+)in the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;the levels of CD8^(+)in the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of AMS and lipase in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6 and TNF-αin the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Xuebijing combined with Somatostatin

关 键 词：重症急性胰腺炎 血必净 生长抑素 血清淀粉酶 脂肪酶 炎性因子 T细胞亚群 

分 类 号：R576[医药卫生—消化系统]