热敏灸治疗干眼的疗效观察  

Observation on the Therapeutic Effect of Heat-sensitive Moxibustion in Treating Dry Eye

作　　者：林艳梅 周斌 钱晓曼 田宁 谢丁一[4] LIN Yanmei;ZHOU Bin;QIAN Xiaoman;TIAN Ning;XIE Dingyi(Guangzhou University of Chinese Medicine,Guangzhou 510006,China;Guangdong Provincial Traditional Chinese and Western Medicine Hospital,Foshan 528253,China;Jinan University,Guangzhou 510632,China;The Affiliated Hospital of Jiangxi University of Chinese Medicine,Nanchang 330009,China)

机构地区：[1]广州中医药大学,广州510006 [2]广东省中西医结合医院,佛山528253 [3]暨南大学,广州510632 [4]江西中医药大学附属医院,南昌330009

出　　处：《中国中医眼科杂志》2025年第4期330-335,350,共7页China Journal of Chinese Ophthalmology

基　　金：江西省重大研发专项项目(20232ACG01006)。

摘　　要：目的观察热敏灸治疗干眼的临床疗效。方法纳入2023年8月—2023年10月于广东省中西医结合医院诊治的干眼患者64例(64只眼),证属肝肾阴虚证。双眼患病者取荧光素染色泪膜破裂时间(FBUT)或泪液分泌试验(SⅠT)较重的眼别入组,若双眼程度相等,则纳入右眼。对照组予健康宣教联合0.1%玻璃酸钠滴眼液;观察组予健康宣教联合热敏灸治疗。2组均治疗30 d。分别于治疗前、后检测受试者的FBUT、角膜荧光染色(FL)阳性率、SⅠT和眼部症状评分。结果(1)FBUT:治疗前后比较,2组治疗后FBUT均较治疗前延长,差异均有统计学意义(t_(对照组)=4.320、t_(观察组)=5.090,均P=0.000)。治疗后2组间比较,观察组FBUT长于对照组,差异有统计学意义(t=2.627,P=0.011)。(2)FL阳性率:2组治疗前FL阳性率比较,差异无统计学意义(P>0.05)。治疗后,2组FL染色均为阴性。(3)SⅠT:治疗前后比较,2组治疗后SⅠT均较治疗前延长,差异均有统计学意义(t_(对照组)=12.782、t_(观察组)=19.094,均P=0.000)。治疗后2组间比较,观察组SⅠT长于对照组,差异有统计学意义(t=4.983,P=0.000)。(4)眼部症状评分:治疗前后比较,2组治疗后眼疲劳(t_(对照组)=4.877、t_(观察组)=5.951,均P=0.000)、异物感(t_(对照组)=2.641,P=0.010;t_(观察组)=5.453,P=0.000)、干涩感(t_(对照组)=8.004、t_(观察组)=5.719,均P=0.000)、烧灼感(t_(对照组)=2.865,P=0.006;t_(观察组)=3.084,P=0.003)、眼胀感(t_(对照组)=4.037、t_(观察组)=5.147,均P=0.000)、眼痛感(t_(对照组)=4.361、t_(观察组)=4.460,均P=0.000)、畏光(t_(对照组)=4.950、t_(观察组)=4.997,均P=0.000)、眼红(t_(对照组)=4.416、t_(观察组)=3.944,均P=0.000)均较治疗前降低,差异均有统计学意义。治疗后2组间异物感得分差值比较,观察组高于对照组,差异有统计学意义(t=2.452,P=0.017)。余组间比较,均无统计学意义(P>0.05)。(5)临床疗效:观察组总有效率为78.1%,高于对照组的53.1%OBJECTIVE To observe the clinical efficacy of heat-sensitive moxibustion in the treatment of dry eye.METHODS A total of 64 patients(64 eyes)with dry eye syndrome diagnosed and treated at Guangdong Provincial Traditional Chinese and Western Medicine Hospital from August 2023 to October 2023 were enrolled,and all were classified as having liver-kidney Yin deficiency syndrome.For patients with bilateral eyes involvement,the eye with a shorter fluorescein break-up time(FBUT)or a shorter SchirmerⅠtest(SⅠT)was enrolled.If both eyes had equal severity,the right eye was enrolled.They were randomly divided into control group(CG)and observation group(OG),32 cases(32 eyes)in each group.The control group received health education combined with 0.1%sodium hyaluronate eye drops,while the treatment group received health education combined with heat-sensitive moxibustion.Both groups were treated for 30 days.Before and after treatment,the FBUT,fluorescent staining(FL)positive rate,SⅠT,and ocular symptom scores were measured for each subject.RESULTS(1)FBUT:After treatment,the FBUT was prolonged in both groups compared with before treatment,with statistically significant differences(t_(CG)=4.320,t_(OG)=5.090,both P=0.000).Comparison between the two groups after treatment showed that the FBUT in the observation group was longer than that in the control group,with a statistically significant difference(t=2.627,P=0.011).(2)FL positive rate:There was no statistically significant difference in the FL positive rate between the two groups before treatment(P>0.05).After treatment,FL staining was negative in both groups.(3)SⅠT:After treatment,SⅠT was lower in both groups compared with before treatment,with statistically significant differences(t_(CG)=12.782,t_(OG)=19.094,both P=0.000).Comparison between the two groups after treatment showed that SⅠT in the observation group was longer than that in the control group,with a statistically significant difference(t=4.983,P=0.000).(4)Ocular symptom scores:After treatment,the scores fo

关 键 词：热敏灸 艾灸 干眼 

分 类 号：R774.1[医药卫生—眼科] R276.7[医药卫生—临床医学]