分批补料发酵工艺参数优化对D-泛酸钙生产的影响研究  

Study on the Effect of Batch Feeding Fermentation Process Parameter Optimization on the Production of D-Calcium Pantothenate

作　　者：孔维政 Kong Weizheng(Hunan Food and Drug Vocational College,Changsha Hunan 410000,China)

机构地区：[1]湖南食品药品职业学院,湖南长沙410000

出　　处：《山西化工》2025年第3期114-116,共3页Shanxi Chemical Industry

基　　金：2023年湖南省教育厅科学研究项目(23C0790)。

摘　　要：本研究探讨了分批补料发酵工艺参数优化对D-泛酸钙生产的影响。通过优化发酵过程中的温度、pH值、溶氧浓度等关键工艺参数,研究表明,合理的工艺条件能够显著提高D-泛酸钙的产量,同时降低副产物的生成。在补料策略方面,研究比较了定时补料、按需补料和渐进式补料三种方式,结果显示,渐进式补料策略能够更有效地平衡微生物的生长和代谢,显著提高产品的合成效率。通过多次重复实验验证,优化后的工艺参数具有较好的稳定性和重复性,确保了生产过程的可控性和一致性。研究结果为D-泛酸钙的工业化生产提供了有效的工艺优化策略,并为其他生物发酵产品的生产工艺改进提供了参考。This study explores the effect of optimizing batch feeding fermentation process parameters on the production of D-calcium pantothenate.By optimizing key process parameters such as temperature,pH value,and dissolved oxygen concentration during the fermentation process,research has shown that reasonable process conditions can significantly increase the yield of D-calcium pantothenate while reducing the generation of by-products.In terms of feeding strategies,the study compared three methods:timed feeding,on-demand feeding,and progressive feeding.The results showed that the progressive feeding strategy can more effectively balance the growth and metabolism of microorganisms,significantly improving the synthesis efficiency of the product.Through multiple repeated experiments,it has been verified that the optimized process parameters have good stability and repeatability,ensuring the controllability and consistency of the production process.The research results provide effective process optimization strategies for the industrial production of D-calcium pantothenate,and provide reference for the improvement of production processes of other biological fermentation products.

关 键 词：分批补料 发酵工艺 D-泛酸钙 工艺优化 补料策略 

分 类 号：X705[环境科学与工程—环境工程]