从病理学角度探讨卵巢浆液性肿瘤的新进展  

New Progress of Serous Ovarian Tumors from the Perspective of Pathology

作　　者：刘君行 LIU Jun-xing(Xuzhou Medical University,Xuzhou Jiangsu 221000,China)

机构地区：[1]徐州医科大学第二临床医学院,江苏徐州221000

出　　处：《泰州职业技术学院学报》2025年第2期80-82,86,共4页Journal of Taizhou Polytechnic College

摘　　要：卵巢浆液性肿瘤(serous tumour,ST)包含多种病理学亚型,具有不同的组织学形态和生物学行为,预后差异显著。其中作为恶性生物学行为的卵巢浆液性腺癌,依据临床行为和组织病理学相关特征,分为低级别浆液性腺癌和高级别浆液性腺癌,两者的发生路径、遗传基因的改变均不相同。尤其是高级别浆液性腺癌,在卵巢癌中死亡率最高,由于缺乏有效的早期筛查手段,经常原发灶很小却已发生广泛播散。卵巢ST的明确诊断依赖手术后的标本送病理检查。文章从病理学角度探讨卵巢ST的来源、不同生物学行为相关的组织学形态和遗传学改变的新进展,以便为临床治疗提供精准诊断。Ovarian serous tumors(ST)encompassed a variety of pathological subtypes,each exhibiting distinct histological features and biological behaviors,with significant prognostic differences.Among them,ovarian serous adenocarcinoma(SAC)that exhibited malignant biological behavior was classified into low-grade SAC and high-grade SAC based on the clinical behavior and histopathological characteristics.The pathways of their occurrence and the alterations in genetic genes were both different.High-grade SAC had the highest mortality rate among ovarian cancers.Due to the lack of effective early screening methods,it often presented with a small primary lesion but had already widely metastasized.The definitive diagnosis of ovarian ST relied on pathological examination of the postoperative specimens.This article reports the origin of ovarian ST from a pathological perspective,new advancements in histological morphology and genetic changes associated with different biological behaviors,aiming to provide precise diagnostics for personalized clinical treatment.

关 键 词：卵巢 肿瘤 浆液性肿瘤 基因 

分 类 号：R737.31[医药卫生—肿瘤]