融合脑网络的多模态三维可视化技术在脑胶质瘤手术个体化解剖的应用分析  

Application and analysis of multimodal 3-D visualization technology integrating brain networks in individualized anatomy of glioma surgery

作　　者：毛星刚 杨秋子 姬昂 吕瑞 孙季冬 张雷 罗鹏 蒋晓帆 Mao Xinggang;Yang Qiuzi;Ji Ang;Lv Rui;Sun Jidong;Zhang Lei;Luo Peng;Jiang Xiaofan(Department of Neurosurgery,Xijing Hospital,Air Force Military Medical University,Xi'an,Shaanxi 710032,China)

机构地区：[1]空军军医大学西京医院神经外科,陕西西安710032

出　　处：《中国微侵袭神经外科杂志》2025年第1期12-18,共7页Chinese Journal of Minimally Invasive Neurosurgery

基　　金：国家自然科学基金资助项目(编号:82273978,81972359);西京创新研究院联合创新基金(编号:LHJJ24YX19)。

摘　　要：目的 探讨融合脑网络的多模态三维可视化技术在脑胶质瘤手术个体化的应用价值。方法 通过2例典型胶质瘤患者影像学资料,采用融合脑网络的数字化多模态三维重建技术,显示脑功能分区、动静脉及神经纤维束的形态及解剖关系,并可据此构建个体化的解剖标志。依据这些标记,在术中显露大脑后,可协助准确判断脑功能区位置及其深部的神经纤维束等结构。结果 2例胶质瘤患者手术切除满意,未出现感觉、运动功能障碍。2例胶质瘤患者在融合脑网络的数字化多模态三维重建技术辅助下,在术前通过脑回形态及周围毗邻的动静脉结构,标定脑胶质瘤范围及周围脑功能分区。进一步通过脑网络的可视化,标定重要神经纤维束与脑功能区的位置关系,包括皮质脊髓束、弓状束、视放射等,从而为手术中保护脑功能区及重要神经纤维束提供定位参考。结论 融合脑网络的多模态三维可视化技术具有直观性、易推广、易使用和个体化的特点,可作为胶质瘤手术规划的重要方法。Objective To explore the application value of multimodal 3-D visualization technology integrating brain networks in the individualization of glioma surgery.Methods Based on the imaging data of 2 patients with typical gliomas,the digital multimodal 3-D reconstruction technology that integrates brain networks was used to display the morphology and anatomical relationships of brain functional areas,arteriovenous and nerve fiber bundles.In addition,personalized anatomical landmarks were constructed based on this.During surgery when exposing the cerebral cortex,these anatomical landmarks were used to assist in accurately determining the location of brain functional areas and their deep neural fiber bundles and other structures.Results Both patients underwent satisfactory glioma resection without sensory or motor dysfunction.With the assistance of 3D visualization technology integrating brain networks,two glioma patients were demarcated by gyrus morphology and surrounding arteriovenous structures before surgery to determine the scope of glioma and the functional zoning of the surrounding brain.Furthermore,through the visualization of the brain network,the position relationship between important nerve fiber tracts and brain functional areas,including corticospinal tracts,arcuate tracts,optic radiation,etc.,can be used to provide a positioning reference for protecting brain functional areas and important nerve fiber tracts during surgery.Conclusions The 3D visualization technology integrating brain networks is intuitive,easy to promote,easy to use and individualized,and can be used as an important method for glioma surgical planning.

关 键 词：神经胶质瘤 脑网络 多模态 数字化 神经纤维束 个体化解剖标记 

分 类 号：R739.41[医药卫生—肿瘤] R730.264[医药卫生—临床医学]