基于PSO-BSA启发式算法对扑热息痛和抗坏血酸混合溶液的精确预测  

Accurate Prediction of Paracetamol and Ascorbic Acid Mixed Solutions Based on PSO-BSA Heuristic Algorithm

作　　者：郭博瑜 鲍涵阳 饶志康 刘哲 徐莹 Guo Boyu;Bao Hanyang;Rao Zhikang;Liu Zhe;Xu Ying(Institute of Instrument Science and Engineering,School of Automation,Hangzhou Dianzi University,Hangzhou 310018,China)

机构地区：[1]杭州电子科技大学自动化学院,杭州310018

出　　处：《中国生物医学工程学报》2024年第6期702-711,共10页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金(61871165);浙江省自然科学基金(LY23F010008)。

摘　　要：本研究构建了同时检测扑热息痛(PA)和抗坏血酸(AA)浓度的电化学检测方法。通过三电极电化学工作站采集实验数据,利用滴涂法和循环伏安法(CV)制备PBs/cMWCNTs/GCE电化学传感器,使得PA和AA的峰电位实现基本分离;通过差分脉冲伏安法(DPV)和计时电流法(CA)对不同浓度的PA和AA混合溶液进行电化学检测,对检测曲线进行典型电化学特征和图像特征进行提取。然后,利用改进型粒子群优化-回溯搜索算法(PSO-BSA)网络对实验数据解耦合,构建对混合样本中PA和AA的浓度准确预测模型,最终实现对PA和AA双化学药物的同时检测。预测结果的拟合度(R2)达到0.995,均方根误差(RMSE)达到0.137 mM,平均绝对误差(MAE)达到0.124 mM。本研究提出的方法具有操作方便、拟合优度高、成本效益高的优势,利于实现PA和AA混合药物的协同检测结果,并实现对某一药样成分的精确分析。In this paper,an electrochemical detection method for simultaneous detection of paracetamol(PA)and ascorbic acid(AA)concentrations was investigated.Experimental data were collected through a three-electrode electrochemical workstation,and PBs/cMWCNTs/GCE electrochemical sensors were prepared using cyclic voltammetry(CV),which resulted in basic separation of the peak potentials of PA and AA.Differential pulse voltammetry(DPV)and chronoamperometry(CA)were used to conduct electrochemical detection of PA and AA mixed solutions with different concentrations,and typical electrochemical features and image features of the detection curves were extracted.Then,the improved particle swarm optimization-backtracking search algorithm(PSO-BSA)network was used to decouple the experimental data and construct an accurate prediction model for the concentration of PA and AA in the mixed sample.Finally,the simultaneous detection of PA and AA dual-chemical drugs was achieved.The R-Square(R2)of the prediction results reached 0.995,the root mean square error(RMSE)reached 0.137 mM,and the mean absolute error(MAE)reached 0.124 mM.The method proposed in this study has the advantages of easy operation,satisfactory goodness of fit,and high cost-effectiveness,which is conducive in achieving synergistic detection results of PA and AA mixed drugs and achieving accurate analysis of the components of a certain drug sample.

关 键 词：混合药样同时检测 粒子群优化-回溯搜索算法 纳米修饰电极 启发式算法 

分 类 号：R318[医药卫生—生物医学工程]