间充质干细胞制备的纳米囊泡在疾病治疗中的研究进展  

Advances in the application of mesenchymal stem cells-derived nanovesicle in various diseases

作　　者：卓馨怡 祝宇翀 刘军权 廖雨琴 Zhuo Xinyi;Zhu Yuchong;Liu Junquan;Liao Yuqin(Zhejiang Weiwei Biopharmaceutical Technology Co.,Ltd.,Hangzhou 310053,Zhejiang;School of Medical Technology and Information Engineering,Zhejiang University of Traditional Chinese Medicine,Clinical Laboratory Diagnosis,Class of 2023,Hangzhou 310053,China)

机构地区：[1]浙江卫未生物医药科技有限公司,杭州310053 [2]浙江中医药大学医学技术与信息工程学院2023级临床检验诊断学,杭州310053

出　　处：《中华细胞与干细胞杂志(电子版)》2025年第1期57-62,共6页Chinese Journal of Cell and Stem Cell(Electronic Edition)

基　　金：国家自然科学基金(82072512)。

摘　　要：间充质干细胞制备的纳米囊泡(MSCNVs)作为一种新型的细胞治疗替代方案,具有稳定性高和体积小等优势,其应用前景已在神经系统疾病、心血管疾病、炎症性疾病和组织再生修复等多个领域得到证实。研究表明,纳米囊泡(NVs)通过促进组织再生、减轻炎症反应和调节免疫应答等机制,在疾病的治疗和组织修复中发挥积极作用。然而,目前MSCNVs在疾病应用中仍面临有效性和长期安全性等挑战,需进一步研究改进。本综述引用最新的研究成果和试验数据,系统性分析MSCNVs在多种疾病治疗中的应用和疗效,以全面且更新的视角展望MSCNVs在疾病治疗中的潜在价值。Mesenchymal stem cell derived nanovesicles(MSCNVs)represent an innovative cellular therapy alternative,characterized by high stability and reduced size,with therapeutic potential validated across various fields,including the nervous system disease,cardiovascular health,inflammatory diseases,as well as tissue regeneration and repair.Studies indicate that nanovesicles(NVs)exert positive effects on disease treatment and tissue repair through mechanisms such as promoting tissue regeneration,alleviating inflammatory responses,and modulating immune responses.However,MSCNVs still confront challenges regarding efficacy and long-term safety in current disease applications,necessitating further research and optimization.This review integrates the latest research findings and experimental data,providing a systematic analysis of the applications and therapeutic efficacy of MSCNVs in the treatment of various diseases,offering a comprehensive and updated perspective on the potential value of MSCNVs in disease therapy.

关 键 词：间充质干细胞 纳米囊泡 治疗 评估 

分 类 号：R73[医药卫生—肿瘤]