血清α-辅肌动蛋白4 细胞间粘附分子-1 铁蛋白及人乳头瘤病毒检测在围绝经期宫颈癌患者手术预后评估中的应用价值分析  

Analysis on the application value of serumα-actinin 4,intercellular adhesion molecule-1,ferritin,and human papillomavirus detection in surgical prognosis evaluation of perimenopausal cervical cancer patients

作　　者：丁怡羚 杨微微 许晓莺 冯伟良 DING Yi-ling;YANG Wei-wei;XU Xiao-ying;FENG Wei-liang(Department of Laboratory Medicine,Huzhou Traditional Chinese Medicine Hospital,Huzhou,Zhejiang 313000,China;不详)

机构地区：[1]湖州市中医院检验科,浙江湖州313000 [2]湖州市妇幼保健院妇产科 [3]杭州市拱墅区半山街道社区卫生服务中心检验科 [4]湖州市中医院药剂科

出　　处：《中国妇幼保健》2025年第6期1123-1127,共5页Maternal and Child Health Care of China

基　　金：浙江省自然科学基金项目(2020035Y072)。

摘　　要：目的探讨血清α-辅肌动蛋白4、细胞间粘附分子-1(ICAM-1)、铁蛋白及人乳头瘤病毒(HPV)检测在围绝经期宫颈癌患者手术预后评估中的应用价值。方法收集2021年5月—2022年10月湖州市中医院和湖州市妇幼保健院收治的围绝经期宫颈癌患者70例为宫颈癌组,宫颈良性肿瘤患者40例为宫颈良性肿瘤组,围绝经期健康女性40例为健康对照组。采集空腹外周静脉血,采用酶联免疫吸附法检测血清α-辅肌动蛋白4、ICAM-1、铁蛋白水平。从宫颈表面病变部位收集脱落的细胞进行培养,采用PCR法检测HPV的类型和数量。收集围绝经期宫颈癌患者的组织学类型、组织学分级、FIGO分期、肿瘤最大径、淋巴结转移、宫颈浸润深度。患者术后定期复查,记录宫颈癌复发情况。结果宫颈癌组血清α-辅肌动蛋白4[(50.37±7.51)pg/ml]、ICAM-1[(28.13±2.46)ng/ml]、铁蛋白[(279.61±12.80)ng/ml]水平均明显高于宫颈良性肿瘤组[(39.62±5.39)pg/ml、(15.04±1.39)ng/ml、(116.82±7.63)ng/ml]和健康对照组[(34.18±4.05)pg/ml、(7.36±0.72)ng/ml、(67.15±3.92)ng/ml],差异均有统计学意义(t=21.849、13.527、37.192,均P<0.05;t=31.938、22.839、45.710,均P<0.05);宫颈良性肿瘤组血清α-辅肌动蛋白4、ICAM-1、铁蛋白水平均明显高于健康对照组(t=9.381、12.904、30.721,均P<0.05)。健康对照组女性HPV筛查未发现高危型HPV感染。宫颈癌组患者高危型HPV感染阳性率(81.43%)明显高于宫颈良性肿瘤组(22.50%),差异有统计学意义(χ^(2)=35.149,P<0.05)。复发组患者血清α-辅肌动蛋白4[(57.83±14.25)pg/ml]、ICAM-1[(33.02±3.29)ng/ml]、铁蛋白[(354.45±17.87)ng/ml]水平及高危型HPV感染率(89.47%)均明显高于未复发组[(47.59±11.86)pg/ml、(26.31±2.15)ng/ml、(251.73±10.91)ng/ml、78.43%],差异均有统计学意义(t=14.649、11.587、47.032,χ^(2)=15.915,均P<0.05)。受试者工作特征(ROC)曲线分析显示:血清α-辅肌动蛋白4、ICAM-1、铁蛋白及高Objective To explore the application value of serumα-actinin 4,intercellular adhesion molecule-1(ICAM-1),ferritin,and human papillomavirus(HPV)detection in surgical prognosis evaluation of perimenopausal cervical cancer patients.Methods Seventy patients with cervical cancer during perimenopausal period admitted to Huzhou Traditional Chinese Medicine Hospital and Huzhou Maternal and Child Health Care Hospital from May 2021 to October 2022 were selected as cervical cancer group,forty patients with benign cervical tumor were selected as cervical benign tumor group,and forty healthy women during perimenopausal period were selected as healthy control group.Fasting peripheral venous blood samples were collected,enzyme-linked immunosorbent assay was used to detect serum levels ofα-actinin 4,ICAM-1,and ferritin.The exfoliated cells from cervical surface lesion site were collected for culture,and PCR method was used to detect the type and quantity of HPV.Histological type,histological grade,FIGO staging,maximum tumor diameter,lymph node metastasis,and depth of cervical invasion of perimenopausal cervical cancer patients were collected.The patients underwent regular follow-up examination after surgery to record the recurrence of cervical cancer.Results The levels of serumα-actinin 4[(50.37±7.51)pg/ml],ICAM-1[(28.13±2.46)ng/ml],and ferritin[(279.61±12.80)ng/ml]in cervical cancer group were statistically significantly higher than those in cervical benign tumor group[(39.62±5.39)pg/ml,(15.04±1.39)ng/ml,(116.82±7.63)ng/ml]and healthy control group[(34.18±4.05)pg/ml,(7.36±0.72)ng/ml,(67.15±3.92)ng/ml],there were statistically significant differences(t=21.849,13.527,37.192,all P<0.05;t=31.938,22.839,45.710,all P<0.05).The levels of serumα-actinin 4,ICAM-1,and ferritin in cervical benign tumor group were statistically significantly higher than those in healthy control group(t=9.381,12.904,30.721,all P<0.05).No high-risk HPV infection was found in HPV screening of healthy control group women.The positive rate of high-

关 键 词：宫颈癌 围绝经期 α-辅肌动蛋白4 细胞间粘附分子-1 铁蛋白 人乳头瘤病毒 预后评估 

分 类 号：R737.33[医药卫生—肿瘤]