错配修复蛋白在老年散发性结直肠癌患者癌组织中的表达及临床意义  

Expression and Clinical Significance of Mismatch Repair Proteins in Cancer Tissues of Elderly Patients with Sporadic Colorectal Cancer

作　　者：朱彦杰 董小华 李航 ZHU Yan-jie;DONG Xiao-hua;LI Hang(Department of Pathology,Kaifeng Central Hospital,Kaifeng,Henan475000;Department of Clinical Laboratory,Kaifeng Central Hospital,Kaifeng,Henan475000)

机构地区：[1]开封市中心医院,病理科,河南开封475000 [2]开封市中心医院,检验科,河南开封475000

出　　处：《中国肛肠病杂志》2025年第2期13-15,共3页Chinese Journal of Coloproctology

基　　金：河南省医学科技攻关计划联合共建项目(编号LHGJ20191169)。

摘　　要：目的:探讨错配修复蛋白(MMRP)在老年散发性结直肠癌患者癌组织中的表达,并分析其与临床病理特征及预后的关系。方法:以2020年5月至2021年4月我院收治的82例老年散发性结直肠癌患者为研究对象,取癌组织标本进行MMRP(包括MLH1、PMS2、MSH2和MSH6)检测,且术后随访至少3年。分析MMRP表达与临床病理特征及术后3年总生存(OS)率和无病生存(DFS)率等的相关性。结果:82例患者中,16例(19.51%)MMRP表达缺失,66例(80.49%)MMRP表达完整。MMRP表达缺失组与表达完整组患者肿瘤直径、TNM分期、组织分化程度、脉管癌栓、淋巴结转移情况方面差异均有统计学意义,P<0.05。相较于MMRP表达完整组患者3年OS率(43.94%,29/66)、3年DFS率(33.33%,22/66),MMRP表达缺失组患者3年OS率(68.75%,11/16)、3年DFS率(56.25%,9/16)明显提高,P<0.05。结论:老年散发性结直肠癌患者MMPR表达与其临床病理特征及预后相关,MMPR检测可能有助于预测老年散发性结直肠癌患者病情及预后,具有一定应用价值。Objective To investigate the expression of mismatch repair proteins(MMRP)in cancer tissues of elderly patients with sporadic colorectal cancer and analyze their relationship with clinicopathological features and prognosisM.I ethods A total of 82 elderly patients with sporadic colorectal cancer admitted to our hospital from May 2020 to April 2021 were selected as the research subjects.Cancer tissue specimens were taken for MMRP(including MLHl,PMS2,MSH2 and MSH6)detection,and postoperative follow-up was conducted for at least 3 years.The correlation between MMRP expression and clinicopathological features,3-year overall survival(OS)rate and disease-free survival(DFS)rate after operation was analyzed.Results Among the 82 patients,16 cases(19.51%)showed loss of MMRP expression and 66 cases(80.49%)had intact MMRP expression.There were significant differences in tumor diameter,TNM stage,degree of histological differentiation,vascular tumor thrombus and lymph node metastasis between the loss of MMRP expression group and the intact MMRP expression group(P<0.05).The 3-year OS rate(68.75%,11/16)and 3-year DFS rate(56.25%,9/16)of the loss of MMRP expression group were significantly higher than those of the intact MMRP expression group(43.94%,29/66;33.33%,22/66,P<0.05).Conclusion The expression of MMPR in elderly patients with sporadic colorectal cancer is related to their clinicopathological features and prognosis.MMPR detection may help predict the condition and prognosis of elderly patients with sporadic colorectal cancer and has certain application value.

关 键 词：散发性结直肠癌 老年人 错配修复蛋白 临床病理特征 预后 

分 类 号：R735.3[医药卫生—肿瘤]