血清CA125、CA19-9、CA724联合检测预测结直肠癌术后复发转移的价值  

Value of Combined Detection of Serum CA125,CA19-9 and CA724 in Predicting Postoperative Recurrence and Metastasis of Colorectal Cancer

作　　者：李宁坡 李恒民 甄洋 LI Ning-po;LI Heng-min;ZHEN Yang(Baofeng Branch,Pingdingshan Second People's Hospital,Pingdingshan,Henan 467000)

机构地区：[1]平顶山市第二人民医院宝丰分院,河南平顶山467000

出　　处：《中国肛肠病杂志》2025年第2期16-18,共3页Chinese Journal of Coloproctology

摘　　要：目的:探讨血清糖类抗原125(CA125)、糖类抗原19-9(CA19-9)、糖类抗原724(CA724)联合检测预测结直肠癌术后复发转移的价值。方法:回顾性收集2021年1月至2022年12月于我院行结直肠癌根治术治疗的150例患者资料,患者均随访至2024年6月,根据随访结果分为复发转移组和未复发转移组,比较2组患者术前血清CA125、CA19-9、CA724水平,绘制受试者工作特征(ROC)曲线,计算术前血清CA125、CA19-9、CA724预测结直肠癌复发转移的的最佳截断值,分析单项或联合预测结直肠癌术后复发转移的价值。结果:复发转移组与未复发转移组患者性别、年龄、TNM分期、肿瘤分化程度、肿瘤部位比较差异均无统计学意义,P>0.05。复发转移组患者术前CA125、CA19-9、CA724水平均高于未复发转移组,差异有统计学意义,P<0.05。CA125、CA19-9、CA724的Cut-off分别为44.39 U/mL、51.72 U/mL、11.53 U/mL时,预测结直肠癌复发转移的AUC (95%CI)分别为0.771(0.668~0.878)、0.794(0.683~0.904)和0.729(0.621~0.837),均高于0.7,有中等预测价值。而CA125、CA19-9、CA724联合预测结直肠癌复发转移的AUC(95%CI)为0.919(0.856~0.982),敏感度和特异度分别为93.27%、80.73%,均高于CA125、CA19-9、CA724单项预测。结论:结直肠癌患者术前CA125、CA19-9、CA724水平对预测复发转移有一定的价值,联合检测预测价值更高。Objective To investigate the value of combined detection of serum carbohydrate antigen 125(CA125),CA19-9 and CA724 in predicting postoperative recurrence and metastasis of colorectal cancer.Methods The data of 150 patients who underwent radical resection of colorectal cancer in our hospital from January 2021 to December 2022 were retrospectively collected.All patients were followed up to June 2024.According to the follow-up results,they were divided into the recurrence and metastasis group and the non-recurrence and metastasis group.The receiver operating characteristic(ROC)curve was drawn to calculate the optimal Cut-off values of preoperative serum CA125,CA19-9 and CA724 for predicting recurrence and metastasis of colorectal cancer,and the value of single or combined prediction of recurrence and metastasis of colorectal cancer after operation was analyzed.Results There was no significant difference in gender,age,TNM staging,tumor differentiation and tumor location between the recurrence and metastasis group and the non-recurrence and metastasis group(P>0.05).The preoperative levels of CA125,CA19-9 and CA724 in the recurrence and metastasis group were higher than those in the non-recurrence and metastasis group,and the difference was statistically significant(P<0.05).The Cut-off values of CA125,CA19-9 and CA724 were 44.39 U/mL,51.72 U/mL and 11.53 U/mL,respectively.The AUC(95%CI)of predicting recurrence and metastasis of colorectal cancer were 0.771(0.668-0.878),0.794(0.683-0.904)and 0.729(0.621-0.837),respectively,which were all higher than 0.7 and had a moderate predictive value.The AUC(95%CI)of CA125,CA19-9 and CA724 for combined prediction of recurrence and metastasis of colorectal cancer was 0.919(0.856-0.982),the sensitivity and specificity were 93.27%and 80.73%,respectively,which were higher than single prediction of CA125,CA19-9 and CA724.Conclusion The preoperative levels of CA125,CA19-9 and CA724 in patients with colorectal cancer have cer-tain value in predicting the recurrence and metastasis,and the

关 键 词：糖类抗原125 糖类抗原19-9 糖类抗原724 结直肠癌 术后 复发转移 预测 

分 类 号：R735.3[医药卫生—肿瘤]