血清糖类抗原125、糖类抗原72-4及血小板与淋巴细胞比值联合检测对结直肠癌手术患者预后的预测价值  

Predictive value of serum carbohydrate antigen 125,carbohydrate antigen 72-4,and platelet-to-lymphocyte ratio combined detection for the prognosis of patients with colorectal cancer undergoing surgery

作　　者：刘海龙 谭首海 于秀芝 李海超 张辰宇 LIU Hailong;TAN Shouhai;YU Xiuzhi;LI Haichao;ZHANG Chenyu(Department of Anorectal,Zhumadian Central Hospital,Zhumadian 463000,He’nan,China)

机构地区：[1]驻马店市中心医院肛肠科,河南驻马店4630000

出　　处：《癌症进展》2025年第3期326-329,共4页Oncology Progress

摘　　要：目的 探讨血清糖类抗原125(CA125)、糖类抗原72-4(CA72-4)及血小板与淋巴细胞比值(PLR)联合检测对结直肠癌手术患者预后的预测价值。方法 选取300例结直肠癌患者,均接受结直肠癌根治术治疗,术前检测CA125、CA72-4、PLR水平。记录所有患者随访2年的预后情况,结直肠癌手术患者预后的影响因素采用Cox比例风险模型分析;绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),评估血清CA125、CA72-4、PLR对结直肠癌手术患者预后的预测价值。结果 随访2年结果显示,300例结直肠癌手术患者中,死亡58例,占比19.33%(58/300)。单因素分析结果显示,预后不良与预后良好患者血清CA125、CA72-4、PLR水平以及临床分期、淋巴结转移情况比较,差异均有统计学意义(P﹤0.05)。多因素Cox回归分析结果显示,血清CA125、CA72-4、PLR升高及临床分期为Ⅲ期、淋巴结转移均为结直肠癌手术患者预后的独立危险因素(P﹤0.05)。ROC曲线结果显示,血清CA125、CA72-4、PLR联合检测预测结直肠癌手术患者预后的AUC为0.895(95%CI:0.851~0.939),高于各指标单独检测。结论 术前血清CA125、CA72-4及PLR联合检测对结直肠癌手术患者预后的预测价值较高,术前血清CA125、CA72-4及PLR水平升高是结直肠癌手术患者预后的危险因素。Objective To investigate the value of preoperative serum carbohydrate antigen 125(CA125),carbohydrate antigen 72-4(CA72-4),and platelet-to-lymphocyte ratio(PLR)combined detection for the prognosis of patients with colorectal cancer undergoing surgery.Method A total of 300 patients with colorectal cancer were selected,all of whom underwent radical surgery for colorectal cancer,the preoperative levels of CA125,CA72-4,and PLR were measured.Record the prognosis of patients followed up for 2 years,and the prognostic influence factors of patients with colorectal cancer undergoing surgery were analyzed by Cox proportional hazards model.The receiver operating characteristic(ROC)curve was drawn,the area under the curve(AUC)was calculated,and the serum CA125,CA72-4,and PLR single and combined detected in predictive of prognosis for patients with colorectal cancer undergoing surgery were evaluated.Result The results of 2-year follow-up showed that among 300 patients with colorectal cancer undergoing surgery,58 cases were died,accounting for 19.33%(58/300).Univariate analysis results showed that there were statistically significant differences in serum CA125,CA72-4,PLR levels,clinical stage,and lymph node metastasis between patients with poor prognosis and patients with good prognosis(P<0.05).Multivariate Cox regression analysis results showed that elevated serum CA125,CA72-4,PLR,clinical stage III,and lymph node metastasis were independent risk factors for the prognosis of patients with colorectal cancer undergoing surgery(P<0.05).The ROC curve results showed that the AUC of the serum CA125,CA72-4,and PLR combined detection in predicting the prognosis of patients with colorectal cancer undergoing surgery was 0.895(95%CI:0.851-0.939),which was higher than the detection of each indicator separately.Conclusion The preoperative serum CA125,CA72-4,and PLR combined detection has high predictive value for the prognosis of patients with colorectal cancer undergoing surgery.Elevated preoperative serum CA125,CA72-4,and PLR levels are

关 键 词：结直肠癌 糖类抗原125 糖类抗原72-4 血小板与淋巴细胞比值 预测价值 

分 类 号：R735.3[医药卫生—肿瘤]