脾多肽注射液联合XELOX方案化疗对晚期结直肠癌患者的治疗效果  

Therapeutic effect of lienal polypeptide injection combined with XELOX regimen chemotherapy in patients with advanced colorectal cancer

作　　者：冯海龙 邢林帅 许召君 雒红涛 王高翔[1] 赫鹏[1] FENG Hailong;XING Linshuai;XU Zhaojun;LUO Hongtao;WANG Gaoxiang;HAO Peng(Department of Colorectal Anorectal Surgery,the First Affiliated Hospital of the Xinxiang Medical University,Xinxiang 453100,He’nan,China)

机构地区：[1]新乡医学院第一附属医院结直肠肛门外科,河南新乡453100

出　　处：《癌症进展》2025年第6期658-661,共4页Oncology Progress

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20200526)。

摘　　要：目的探讨脾多肽注射液联合奥沙利铂+卡培他滨(XELOX)方案化疗对晚期结直肠癌(CRC)患者的治疗效果。方法根据治疗方法的不同将120例晚期CRC患者分为对照组(n=61,XELOX方案化疗)和观察组(n=59,脾多肽注射液联合XELOX方案化疗)。比较两组患者的临床疗效、免疫功能指标[辅助性T细胞(Th)1、Th2、Th1/Th2]、血清肿瘤标志物[癌胚抗原(CEA)、糖类抗原19-9(CA19-9)及糖类抗原72-4(CA72-4)]水平及不良反应发生情况。结果观察组患者疾病控制率为83.05%,高于对照组患者的65.57%,差异有统计学意义(P﹤0.05)。治疗4个周期后,两组患者Th1水平及Th1/Th2均低于本组治疗前,Th2水平均高于本组治疗前,观察组患者Th1水平及Th1/Th2均高于对照组,Th2水平低于对照组,差异均有统计学意义(P﹤0.05)。治疗4个周期后,两组患者CEA、CA19-9、CA72-4水平均低于本组治疗前,观察组患者CEA、CA19-9、CA72-4水平均低于对照组,差异均有统计学意义(P﹤0.05)。两组患者骨髓抑制、胃肠道反应、贫血、感染发生率比较,差异均无统计学意义(P﹥0.05)。结论脾多肽注射液联合XELOX方案化疗对晚期CRC患者的治疗效果显著,可促进免疫平衡,降低肿瘤标志物水平,且具有一定的安全性。Objective To investigate the therapeutic effect of lienal polypeptide injection combined with oxaliplatin+capecitabine(XELOX)regimen chemotherapy in patients with advanced colorectal cancer(CRC).Method According to different treatment methods,120 patients with advanced CRC were divided into control group(n=61,XELOX regimen chemotherapy)and observation group(n=59,lienal polypeptide injection combined with XELOX regimen chemotherapy).The clinical efficacy,immune function indicators[helper T cell(Th)1,Th2,Th1/Th2],serum tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9)and carbohydrate antigen 72-4(CA72-4)]levels and adverse reactions were compared between the two groups.Result The disease control rate in observation group was 83.05%,higher than 65.57%in control group,and the difference was statistically significant(P<0.05).After 4 cycles of treatment,the Th1 level and Th1/Th2 in both groups were lower than those before treatment,and the Th2 levels were higher than those before treatment,the Th1 level and Th1/Th2 in observation group were higher than those in control group,and the Th2 level was lower than that in control group,the differences were statistically significant(P<0.05).After 4 cycles of treatment,the CEA,CA19-9 and CA72-4 levels in both groups were lower than those before treatment,and the CEA,CA19-9 and CA72-4 levels in observation group were lower than those in control group,the differences were statistically significant(P<0.05).There were no significant differences in the incidences of bone marrow suppression,gastrointestinal reaction,anemia and infection between the two groups(P>0.05).Conclusion Lienal polypeptide injection combined with XELOX regimen chemotherapy has a significant therapeutic effect in patients with advanced CRC,which can promote immune balance and reduce the levels of tumor markers,and has certain safety.

关 键 词：结直肠癌 脾多肽注射液 奥沙利铂 卡培他滨 治疗效果 

分 类 号：R735.3[医药卫生—肿瘤]