小儿肝母细胞瘤的超声特征及其与癌胚抗原、甲胎蛋白的相关性  

Ultrasound features of hepatoblastoma in children and its correlation withcarcinoembryonic antigen and α-fetal protein

作　　者：唐奇琼 贾春阳 吴西博[1] 魏郑虎 霍亚玲 王丹[1] TANG Qiqiong;JIA Chunyang;WU Xibo;WEI Zhenghu;HUO Yaling;WANG Dan(Department of Ultrasound Medicine,Children’s Hospital Affiliated to Zhengzhou University/He’nan Children’s Hospital,Zhengzhou Children’s Hospital,Zhengzhou 450018,He’nan,China;Department of Radiology,Children’s Hospital Affiliated to Zhengzhou University/He’nan Children’s Hospital,Zhengzhou Children’s Hospital,Zhengzhou 450018,He’nan,China)

机构地区：[1]郑州大学附属儿童医院/河南省儿童医院郑州儿童医院超声医学科,郑州450018 [2]郑州大学附属儿童医院/河南省儿童医院郑州儿童医院放射科,郑州450018

出　　处：《癌症进展》2025年第6期686-690,共5页Oncology Progress

基　　金：河南省医学科技攻关计划软科学项目及联合共建项目(LHGJ20220762)。

摘　　要：目的探讨小儿肝母细胞瘤的超声特征及其与癌胚抗原(CEA)、甲胎蛋白(AFP)的相关性。方法选取104例肝母细胞瘤患儿,病理类型包括完全上皮细胞型(n=38)、不伴畸胎样混合型(n=26)和伴畸胎样混合型(n=40),比较不同病理类型肝母细胞瘤患儿的临床及超声特征,比较不同临床及超声特征肝母细胞瘤患儿血清AFP、CEA水平;血清AFP、CEA水平与肝母细胞瘤患儿超声特征的相关性采用Spearman相关性分析。结果不同病理类型肝母细胞瘤患儿内部回声、钙化情况比较,差异均有统计学意义(P﹤0.05)。不同病理类型、TNM分期、血管侵犯情况、肿瘤多发情况、治疗前肿瘤范围分期系统(PRETEXT)分期、远处转移情况肝母细胞瘤患儿血清AFP、CEA水平比较,差异均有统计学意义(P﹤0.05)。Spearman相关性分析发现,血清AFP、CEA水平与肝母细胞瘤患儿内部回声、钙化情况、病理类型、TNM分期、血管侵犯情况、肿瘤多发情况、PRETEXT分期、远处转移情况均呈正相关(P﹤0.05)。结论晚期、存在远处转移肝母细胞瘤患儿的血清AFP、CEA水平较高,超声特征中内部回声与血清AFP、CEA水平呈正相关,可作为评估病情的辅助指标,为临床诊断和治疗提供重要参考。Objective To explore the ultrasound features of hepatoblastoma in children and its correlation with carcinoembryonic antigen(CEA)andα-fetal protein(AFP).Method A total of 104 children with hepatoblastoma were selected,which were divided into complete epithelial cell type(n=38),mixed type without teratoma(n=26)and mixed type with teratoma(n=40).The clinical characteristics and ultrasound features of hepatoblastoma children with different pathological types were compared,and the serum AFP and CEA levels of hepatoblastoma children with different clinical characteristics were compared.The correlation between serum AFP and CEA levels and ultrasound features of hepatoblastoma children were analyzed by Spearman correlation analysis.Result The comparison of internal echo and calcification in children with different pathological types of hepatoblastoma showed statistically significant differences(P<0.05).The serum AFP,CEA levels in hepatoblastoma children with different pathological types,TNM staging,vascular invasion,tumor multiplicity,PRE-Treatment EXTent of tumor(PRETEXT)staging,and distant metastasis were compared,and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that serum AFP and CEA levels were positively correlated with internal echo,calcification,pathological type,TNM stage,vascular invasion,tumor multiplicity,PRETEXT stage,and distant metastasis in children with hepatoblastoma(P<0.05).Conclusion The serum levels of AFP and CEA are higher in hepatoblastoma children with advanced stage and distant metastatic.The ultrasound features show significant positive correlation between internal echo and serum AFP and CEA levels,which can serve as auxiliary indicators for evaluating the condition and provide important references for clinical diagnosis and treatment.

关 键 词：肝母细胞瘤 超声特征 癌胚抗原 甲胎蛋白 相关性 

分 类 号：R735.7[医药卫生—肿瘤]