基于循证理论的精细化干预在行异基因造血干细胞移植的急性淋巴细胞白血病患儿中的应用效果  

Application effect of refined intervention based on evidence-based theory in children with acute lymphoblastic leukemia undergoing allogeneic hematopoietic stem cell transplantation

作　　者：韦莹莹[1] 陈志华[1] 石俊梅[1] WEI Yingying;CHEN Zhihua;SHI Junmei(Hematopoietic Stem Cell Transplant Center,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,He’nan,China)

机构地区：[1]郑州大学第一附属医院造血干细胞移植中心,郑州450000

出　　处：《癌症进展》2025年第6期731-734,共4页Oncology Progress

摘　　要：目的探讨基于循证理论的精细化干预在行异基因造血干细胞移植(allo-HSCT)的急性淋巴细胞白血病(ALL)患儿中的应用效果。方法根据干预方法的不同将62例行allo-HSCT的ALL患儿分为对照组(n=36,常规干预)和研究组(n=26,基于循证理论的精细化干预),比较两组患儿的心理状况[汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)]、治疗依从性、并发症发生情况及家属满意度。结果干预后,两组患儿HAMA、HAMD评分均降低,且研究组低于对照组,差异均有统计学意义(P﹤0.05)。研究组患儿的总依从率、家属总满意度高于对照组,差异均有统计学意义(P﹤0.05)。两组患儿并发症总发生率比较,差异无统计学意义(P﹥0.05)。结论基于循证理论的精细化干预应用于行allo-HSCT治疗的ALL患儿中,可以改善治疗依从性、心理状况,提高家属满意度,并且不会增加并发症。Objective To explore the application effect of refined intervention based on evidence-based theory in children with acute lymphoblastic leukemia(ALL)undergoing allogeneic hematopoietic stem cell transplantation(allo-HSCT).Method A total of 62 children with ALL who underwent allo-HSCT were divided into control group(n=36,conventional intervention)and study group(n=26,refined intervention based on evidence-based theory)according to different intervention methods.The psychological status[Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD)],treatment compliance,incidence of complications,and parental satisfaction of the two groups were compared.Result After intervention,the HAMA and HAMD scores of both groups decreased,and the study group were lower than those of the control group,the differences were statistically significant(P<0.05).The total compliance rate and total parental satisfaction of the study group were higher than those of the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the total complication rate between the two groups(P>0.05).Conclusion Refined intervention based on evidence-based theory in children with ALL undergoing allo-HSCT can improve treatment compliance and psychological status,increase parental satisfaction,and does not increase complications.

关 键 词：急性淋巴细胞白血病 异基因造血干细胞移植 循证理论 精细化干预 

分 类 号：R733.71[医药卫生—肿瘤]