血清let-7a、肿瘤坏死因子-α在喉癌中的表达及与患者术后复发的关系  

Expression of serum let-7a and tumor necrosis factor-αin laryngeal cancer and their relationship with postoperative recurrence

作　　者：周航[1] 崔粲 马慧敏[1] 连荣[1] 余文发[1] 王银鑫 ZHOU Hang;CUI Can;MAHuimin;LIAN Rong;YU Wenfa;WANG Yinxin(Department of Otolaryngology,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453100,He’nan,China)

机构地区：[1]新乡医学院第一附属医院耳鼻咽喉科,河南新乡453100

出　　处：《癌症进展》2025年第4期460-463,共4页Oncology Progress

摘　　要：目的探讨血清let-7a、肿瘤坏死因子-α(TNF-α)在喉癌中的表达及与患者术后复发的关系。方法选取67例喉癌患者和54例喉部良性疾病患者,比较喉癌及喉部良性疾病患者血清let-7a、TNF-α水平。随访1年,记录喉癌患者的术后复发情况,喉癌患者术后复发的影响因素采用多因素Logistic回归模型分析;绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),评估血清let-7a、TNF-α对喉癌患者术后复发的预测价值。结果喉癌患者血清let-7a水平低于喉部良性疾病患者,TNF-α水平高于喉部良性疾病患者,差异均有统计学意义(P﹤0.05)。随访1年,67例喉癌患者复发21例,未复发46例,复发患者分化程度为中低分化、TNM分期为Ⅲa期比例均高于未复发患者,血清let-7a水平低于未复发患者,TNF-α水平高于未复发患者,差异均有统计学意义(P﹤0.05)。多因素Logistic回归分析结果显示,let-7a水平升高为喉癌患者术后复发的保护因素(P﹤0.05),TNF-α水平升高为喉癌患者术后复发的危险因素(P﹤0.05)。ROC曲线显示,血清let-7a预测喉癌患者术后复发的AUC为0.837(95%CI:0.736~0.939),高于TNF-α的0.654(95%CI:0.516~0.793)。结论喉癌患者血清let-7a水平降低,TNF-α水平升高。let-7a对喉癌患者的术后复发具有一定的预测价值,有望成为预测喉癌患者预后的生物标志物。Objective To explore the expression of serum let-7a and tumor necrosis factor-α(TNF-α)in laryngeal cancer and their relationship with postoperative recurrence.Method A total of 67 patients with laryngeal cancer and 54 patients with benign laryngeal tumors were selected,and to compare the serum levels of let-7a and TNF-α between them.Follow up for one year,postoperative recurrence of laryngeal cancer patients was recorded,and to analyze the influencing factors of postoperative recurrence of patients with laryngeal cancer by multivariate Logistic regression model.The receiver operating characteristic(ROC)curve was drawn,the area under the curve(AUC)was calculated,and the predictive value of serum let-7a and TNF-α for postoperative recurrence in patients with laryngeal cancer were evaluated.Result The serum let-7a level in patients with laryngeal cancer was lower than that in patients with benign laryngeal diseases,and the TNF-α level was higher than that in patients with benign laryngeal diseases,the differences were statistically significant(P<0.05).During one year follow-up,21 cases out of 67 laryngeal cancer patients experienced recurrence,while 46 did not.The proportion of recurrent patients with low to moderate differentiation and TNM stage IIIa were higher than those of non-recurrent patients,the serum let-7a level was lower than that of non-recurrent patients,and the TNF-α level was higher than that of non-recurrent patients,the differences were statistically significant(P<0.05).Multivariate Logistic regression results showed that elevated level of let-7a was protective factor for postoperative recurrence in laryngeal cancer patients(P<0.05),while elevated level of TNF-α was risk factor for postoperative recurrence in laryngeal cancer patients(P<0.05).The ROC curve showed that the AUC of serum let-7a in predicting postoperative recurrence of laryngeal cancer patients was 0.837(95%CI:0.736~0.939),which was higher than 0.654(95%CI:0.516~0.793)of TNF-α.Conclusion The serum level of let-7a decreases and

关 键 词：喉癌 let-7a 肿瘤坏死因子-Α 术后复发 影响因素 预测价值 

分 类 号：R739.65[医药卫生—肿瘤]