超重及肥胖女性乳腺癌患者癌组织ER、PR、 HER-2及Ki-67表达情况分析  

Analysis of Expression of ER,PR,HER-2 and Ki-67 in Cancer Tissues of Overweight and Obese Female Breast Cancer Patients

作　　者：梁雅静[1] 郝金成[1] LIANG Yajing;HAO Jincheng(Rizhao Hospital of Traditional Chinese Medicine,Rizhao 276800,China)

机构地区：[1]日照市中医医院,山东日照276800

出　　处：《中外医学研究》2025年第8期58-60,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析超重及肥胖女性乳腺癌患者癌组织雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体-2(HER-2)及细胞增殖标志物Ki-67抗原(Ki-67)表达情况。方法:对2021年5月—2023年12月于日照市中医医院接受治疗的160例女性乳腺癌患者的临床资料进行回顾性分析,按照体重指数(BMI)对患者进行分组,BMI≥24.0 kg/m^(2)的83例患者作为研究组,18.5 kg/m^(2)≤BMI<24.0 kg/m^(2)的77例患者作为对照组。对两组癌组织进行免疫组化检测,比较两组癌组织ER、PR、HER-2、Ki-67表达情况及临床特征。结果:160例乳腺癌患者中,癌组织ER、PR、HER-2表达阳性率及Ki-67高表达率分别为76.88%(123/160)、68.13%(109/160)、26.88%(43/160)、81.25%(130/160)。两组PR阳性率、HER-2阳性率及Ki-67高表达率比较,差异无统计学意义(P>0.05);研究组ER阳性率高于对照组,差异有统计学意义(P<0.05)。两组年龄比较,差异无统计学意义(P>0.05);但研究组肿瘤直径>5 cm侵犯皮肤或胸壁、TNM分期Ⅲ~Ⅳ期、低分化、淋巴结转移比例显著高于对照组,差异有统计学意义(P<0.05)。结论:超重及肥胖女性乳腺癌患者癌组织中ER表达更高,乳腺肿瘤直径更大,TNM分期、病理分期更严重,淋巴转移率更高。Objective:To analyze the expressions of estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor receptor-2(HER-2)and cell proliferation marker Ki-67 antigen(Ki-67)in cancer tissues of overweight and obese female breast cancer patients.Method:The clinical data of 160 female breast cancer patients who treated in Rizhao Hospital of Traditional Chinese Medicine from May 2021 to December 2023 were retrospectively analyzed,the patients were grouped according to body mass index(BMI),83 patients with BMI≥24.0 kg/m^(2) were used as the study group,and 77 patients with 18.5 kg/m^(2)≤BMI<24.0 kg/m^(2) were used as the control group.Immunohistochemical detection was performed on two groups of cancer tissues,the expressions of ER,PR,HER-2,Ki-67 and clinical features were compared between two groups.Result:Among 160 female breast cancer patients,the positive rates of ER,PR,HER-2 expression and high expression of Ki-67 were 76.88%(123/160),68.13%(109/160),26.88%(43/160)and 81.25%(130/160),respectively.There were no significant differences in the positive rate of PR,the positive rate of HER-2 and the high expression rate of Ki-67 between two groups(P>0.05);the positive rate of ER in the study group was higher than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in age between two groups(P>0.05);however,the proportion of tumor diameter>5 cm invading skin or chest wall,TNM stageⅢ-Ⅳ,poor differentiation and lymph node metastasis in the study group were significantly higher than those in the control group,and the differences was statistically significant(P<0.05).Conclusion:The expression of ER is higher,tumor diameter is larger,TNM stage and pathological stage are higher,and lymph node metastasis rate is higher in overweight and obese female breast cancer patients.

关 键 词：乳腺癌 超重 肥胖 雌激素受体 孕激素受体 人表皮生长因子受体-2 细胞增殖标志物Ki-67抗原 

分 类 号：R737.9[医药卫生—肿瘤]