丁苯酞联合盐酸多奈哌齐对老年脑梗死后血管性痴呆患者脑血流状态及血清相关因子水平的影响  

The Effect of Butylphthalein Combined with Donepezil Hydrochloride on Cerebral Blood Flow Status and Serum Related Factor Levels in Elderly Patients with Vascular Dementia After Cerebral Infarction

作　　者：张翼[1] ZHANG Yi(The People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China)

机构地区：[1]广西壮族自治区人民医院,广西南宁530021

出　　处：《中外医学研究》2025年第9期60-63,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:对老年脑梗死后血管性痴呆患者实施丁苯酞与盐酸多奈哌齐联合应用治疗及并对患者脑血流状况和血清相关因子水平的作用进行探讨。方法:选取2021年4月-2024年3月在广西壮族自治区人民医院收治的80例老年脑梗死后血管性痴呆患者作为研究对象。按抽签法将其分为对照组和观察组,每组各40例。对照组单独给予盐酸多奈哌齐治疗。观察组则应用丁苯酞联合盐酸多奈哌齐治疗,比较两组的临床疗效、认知功能、脑血流状态、血清相关因子和不良反应发生情况。结果:观察组的治疗总有效率、建议精神状态量表(MMSE)评分、临床痴呆评定量表(CDR)评分、脑血容量(CBV)、脑血流量(CBF)、闹圆形神经营养因子(BDNF)、血清血管紧张素(Ang1-7)、日常生活活动能力量表(ADL)评分均较对照组明显上升,其余指标则明显下降,差异有统计学意义(P<0.05)。比较不良反应发生率,差异无统计学意义(P>0.05)。结论:对脑梗死后发生血管性痴呆的老年患者采用丁苯酞联合盐酸多奈哌齐治疗后,能取得比较满意的效果,能改善脑部的血流状态,调节血清相关因子的水平,对促进认知功能的恢复、提高日常生活的能力十分重要。Objective:The combined treatment of butylphthalein and Donepezil hydrochloride was perrformed in elderly patients with vascular dementia after cerebral infarction,and the effects of cerebral blood flow and serum related factor were discussed.Method:A total of 80 elderly patients with vascular dementia after cerebral infarction who received treatment in the People's Hospital of Guangxi Zhuang Autonomous Region from April 2021 to March 2024 were selected as the study objects.They were divided into control group and observation group,with 40 cases in each group.The control group was treated with Donepezil hydrochloride alone,while the observation group was treated with butylphthalein combined with Donepezil hydrochloride.The clinical efficacy,cognitive function,cerebral blood flow status,serum related factors and the occurrence of adverse reactions were compared between the two groups.Result:The total effective rate,Mini-Mental State Examination(MMSE)score,Clinical Dementia Rating(CDR)score,Cerebral Blood Volume(CBV),Cerebral Blood Flow(CBF),Brain-Derived Neurotrophic Factor(BDNF),Angiotensin 1-7(Ang1-7)and Activities of Daily Living(ADL)score of the observation group were significantly increased compared with the control group,while the other indexes were significantly decreased,with statistical significance(P<0.05).There was no significant difference in the incidence of adverse reactions(P>0.05).Conclusion:In elderly patients with vascular dementia after cerebral infarction,the combination of butylphthalide and Donepezil hydrochloride can achieve satisfactory results,which can improve the blood flow state of the brain,regulate the level of serum related factors,and promote the recovery of cognitive function and improve the ability of daily life.

关 键 词：丁苯酞 盐酸多奈哌齐 脑梗死 血管性痴呆 脑血流状态 血清相关因子 

分 类 号：R743.3[医药卫生—神经病学与精神病学]