玻璃体切除联合康柏西普治疗增殖期糖尿病视网膜病变的效果  

Effect of Vitrectomy Combined with Comacept in Proliferative Diabetic Retinopathy

作　　者：曹二兵 CAO Erbing(Department of Ophthalmology,Jiangning Hospital Affiliated to Nanjing Medical University,Nanjing,Jiangsu,211100,China)

机构地区：[1]南京医科大学附属江宁医院眼科,江苏南京211100

出　　处：《中外医疗》2025年第3期39-42,共4页China & Foreign Medical Treatment

摘　　要：目的 分析在治疗增殖期糖尿病视网膜病变疾病时选择应用玻璃体切除联合康柏西普的疗效。方法前瞻性随机选取2022年6月—2023年12月南京医科大学附属江宁医院接收治疗的90例增殖期糖尿病视网膜病变患者为研究对象,以不同治疗方法分为对照组、观察组,每组45例。对照组采取玻璃体切割,观察组采取玻璃体切除与康柏西普联合治疗。比较两组最佳矫正视力(best-corrected visualacuity, BCVA)、黄斑中心凹视网膜厚度(central retinal thickness, CRT)、并发症总发生率、低视力者生活质量量表(Chinese-version Low Vision Quality of Life Questionnaire, CLVQOL)评分。结果 治疗后,观察组CRT(180.65±54.54)μm低于对照组的(314.38±56.47)μm,BCVA(0.43±0.13)高于对照组的(0.30±0.07),差异均有统计学意义(t=11.427,5.906;P均<0.05)。观察组并发症总发生率低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组CLVQOL评分高于对照组,差异有统计学意义(P<0.05)。结论 在对增殖期糖尿病视网膜病变患者进行治疗时,选择采用玻璃体切除与康柏西普联合方式,疗效比较明显,不仅能降低CRT水平,还可提升BCVA,并发症少,提升生活质量。Objective To analyze the overall effectiveness of vitrectomy combined with compazine in the treatment of patients with proliferative diabetic retinopathy.Methods A total of 90 patients with proliferative diabetic retinopathy who were treated in Jiangning Hospital Affiliated to Nanjing Medical University from June 2022 to December 2023 were prospective randomly selected as the research objects.They were divided into control group and observation group according to different treatment methods,with 45 cases in each group.The control group was treated with vitrec-tomy,and the observation group was treated with vitrectomy combined with conbercept.The best-corrected visual acu-ity(BCVA),central retinal thickness(CRT),the total incidence of complications and Chinese-version Low Vision Quality of Life Questionnaire(CLVQOL)score were compared between the two groups.Results After treatment,the CRT of the observation group was(180.65±54.54)μm lower than that of the control group(314.38±56.47)μm,and the BCVA was(0.43±0.13)higher than that of the control group(0.30±0.07),the differences were statistically signifi-cant(t=11.427,5.906;both P<0.05).The total incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).After treatment,the CLVQOL score of the ob-servation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of patients with proliferative diabetic retinopathy,the combined approach of vitrectomy and compexip is more effective,which not only reduces the level of CRT,but also improves the BCVA,with fewer complications,and improves the quality of life,which is worthy of being promoted as well as implemented in the clini-cal treatment program.

关 键 词：康柏西普 玻璃体切割 增殖期糖尿病视网膜病变 治疗效果 

分 类 号：R774[医药卫生—眼科]