血清肾上腺素、miR-202表达水平与儿童抑郁症严重程度的相关性研究  

Correlation Study on Severity of Childhood Depression with Levels of Serum Adrenaline and miR-202 Expression

作　　者：曹玉婷 崔凤伟[2] 王瑛[2] CAO Yuting;CUI Fengwei;WANG Ying(Department of Psychiatry,Yancheng Fourth People's Hospital,Yancheng Jiangsu 224003)

机构地区：[1]江苏省盐城市第四人民医院精神科,江苏盐城224003 [2]江苏省无锡市精神卫生中心精神科,江苏无锡214151

出　　处：《医学临床研究》2025年第3期387-389,393,共4页Journal of Clinical Research

摘　　要：【目的】探讨血清肾上腺素和miR-202表达水平与儿童抑郁症严重程度的相关性。【方法】107例抑郁症儿童作为观察组,根据儿童抑郁症量表(CDI)评分将其分为轻度组(34例)、中度组(43例)和重度组(30例)。另选取同期100例健康儿童作为对照组。比较各组血清肾上腺素水平、miR-202表达水平,采用Spearman相关性分析其与抑郁症严重程度的关系,并通过受试者工作特征(ROC)曲线分析其在儿童抑郁症诊断中的价值。【结果】观察组血清肾上腺素水平、miR-202的表达水平显著低于对照组(P<0.05)。轻、中、重度组患儿血清肾上腺素水平、miR-202表达水平呈逐渐降低趋势,各组之间比较,差异均有统计学意义(P<0.05)。血清肾上腺素水平、miR-202的表达水平与抑郁症严重程度呈负相关(P<0.05)。血清肾上腺素水平和miR-202联合检测的诊断效能高于两者单独检测。【结论】血清肾上腺素和miR-202表达水平与儿童抑郁症严重程度呈显著相关性,两者联合检测对于儿童抑郁症的诊断和病情评估具有重要价值。【Objective】To investigate the correlation between levels of serum adrenaline and miR-202 expression and the severity of childhood depression.【Methods】A total of 107 children with depression were included in the observation group.Based on the Children's Depression Inventory(CDI),they were divided into the mild group(34 cases),the moderate group(43 cases)and the severe group(30 cases).An additional 100 healthy children were selected as the control group.Serum adrenaline level and miR-202 expression level were compared between the two groups.Spearman correlation analysis was used to assess the relationship between these levels and the severity of depression.Receiver Operating Characteristic(ROC)curve analysis was used to evaluate the diagnostic value of these markers for childhood depression.【Results】Serum adrenaline level and miR-202 expression level in the observation group were significantly lower than those in the control group(P<0.05).Among the mild,moderate,and severe groups,serum adrenaline level and miR-202 expression level showed a gradual decreasing trend,with significant differences among the groups(P<0.05).Serum adrenaline level and miR-202 expression level were negatively correlated with the severity of depression(P<0.05).The diagnostic efficacy of the combined detection of both serum adrenaline and miR-202 was higher than that of either test alone.【Conclusion】Serum adrenaline level and miR-202 expression are significantly correlated with the severity of childhood depression.Combined detection of both markers has important value for diagnosing and assessing the condition of childhood depression.

关 键 词：抑郁症 肾上腺素 微RNAS 数据相关性 儿童 

分 类 号：R749.42[医药卫生—神经病学与精神病学]