早期血液炎症指标与社区获得性肺炎患者病情严重程度的相关性分析  

Correlation Analysis of Early Blood Inflammation Indicators and Severity of Disease in Patients with Community-Acquired Pneumonia

作　　者：张冰姿 李硕 ZHANG Bingzi;LI Shuo(Department of Respiratory Medicine,155th Kaifeng Hospital,Kaifeng Henan 475000)

机构地区：[1]开封一五五医院呼吸内科,河南开封475000

出　　处：《医学临床研究》2025年第3期430-432,共3页Journal of Clinical Research

摘　　要：【目的】探讨早期血液炎症指标与社区获得性肺炎(community-acquired pneumonia,CAP)患者病情严重程度的相关性。【方法】选取2022年11月至2024年5月在本院诊治的99例CAP患者,按照肺炎严重指数(PSI)评分将患者分为轻度组、中度组、重度组。收集患者实验室检测指标及早期血液炎症指标,采用Pearson分析早期血液炎症指标与CAP患者病情严重程度的相关性。【结果】轻度组患者33例(33.33%),中度组患者35例(35.36%),重度组患者31例(31.31%)。轻度组、中度组、重度组总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)、血小板计数、红细胞计数、纤维蛋白原(Fib)比较,差异无统计学意义(P>0.05);重度组患者血钠浓度低于轻度组、中度组;三组患者丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、血尿素氮(BUN)、血乳酸脱氢酶(LDH)、降钙素原(PCT)、C反应蛋白(CRP)、白细胞计数、γ-谷氨酰转肽酶(GGT)、凝血酶时间(TT)、凝血酶原时间(PT)、D-二聚体(DD)比较,差异均具有统计学意义(P<0.05)。Pearson相关性分析结果显示:CAP患者的血钠浓度与PSI评分呈负相关(P<0.05),而ALT、AST、BUN、LDH、PCT、CRP、GGT、TT、PT、DD水平及白细胞计数与PSI评分呈正相关(P<0.05)。【结论】CAP患者病情严重程度与血液中多种因子密切相关,其有助于辅助评估CAP患者病情严重程度。【Objective】To investigate the association between early blood inflammatory markers and the severity of disease in patients with community-acquired pneumonia(CAP).【Methods】A total of 99 patients with CAP treated in our hospital from November 2022 to May 2024 were selected and divided into mild group,moderate group and severe group according to the pneumonia Severity index(PSI)score.Laboratory detection indicators and early blood inflammation indicators of patients were collected,and Pearson was used to analyze the correlation between early blood inflammation indicators and the severity of disease in CAP patients.【Results】There were 33 cases(33.33%)in the mild group,35 cases(35.36%)in the moderate group,and 31 cases(31.31%)in the severe group.There was no significant difference in total bilirubin(TBIL),direct bilirubin(DBIL),indirect bilirubin(IBIL),platelet count,red blood cell count and fibrinogen(Fib)between mild group,moderate group and severe group(P>0.05).The serum sodium concentration of severe group was lower than that of mild group and moderate group.Comparing within the Alanine aminotransferase(ALT),aspartate aminotransferase(AST),blood urea nitrogen(BUN),blood lactate dehydrogenase(LDH),procalcitonin(PCT),C-reactive protein(CRP),white blood cell count,γ-glutamyl transpeptidase(GGT),thrombin time(TT),prothrombin time(PT)and D-dimer in three groups(DD),the differences were statistically significant(P<0.05).Pearson correlation analysis showed that blood sodium concentration was negatively correlated with PSI score in CAP patients(P<0.05),while ALT,AST,BUN,LDH,PCT,CRP,white blood cell count,GGT,TT,PT,DD were positively correlated with PSI score(P<0.05).【Conclusion】The severity of CAP patients is closely related to many factors in the blood,which is helpful to evaluate the severity of CAP patients.

关 键 词：肺炎 社区获得性感染 炎症趋化因子类 病人病情 数据相关性 

分 类 号：R[医药卫生]