雌激素受体、孕激素受体不同表达状态的HER-2阳性乳腺癌患者多模态超声特征分析  

Multimodal Ultrasonographic Analysis of HER-2 Positive Breast Cancer Patients with Different Expression States of Estrogen Receptor and Progesterone Receptor

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作  者:姬利萍 邢国臣 冯培贝 赵玲 易善永 JI Liping;XING Guochen;FENG Peibei(Department of Oncology,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou Henan 450007)

机构地区:[1]郑州大学附属郑州中心医院肿瘤内科,河南郑州450007

出  处:《医学临床研究》2025年第3期433-436,440,共5页Journal of Clinical Research

摘  要:【目的】探讨雌激素受体(ER)、孕激素受体(PR)不同表达状态的人表皮生长因子受体2(HER-2)阳性乳腺癌患者多模态超声特征。【方法】选择2020年5月至2024年3月本院收治的149例HER-2阳性乳腺癌患者,根据免疫组化结果分为A组(n=71,HER-2阳性,ER、PR阴性)、B组(n=27,HER-2阳性,ER或PR阳性)、C组(n=51,HER-2、ER、PR阳性),分析ER、PR不同表达状态下的HER-2阳性乳腺癌患者超声特征。【结果】A组病灶边界不清晰、后方回声为增强、有钙化、内部回声为混合型回声、纵横比>0.7、Adler分级为2~3级、乳腺影像报告和数据系统(BI-RADS)分级为5级占比高于B组、C组(P<0.05),且B组上述指标高于C组(P<0.05)。A组弹性评分≥3分占比、病变组织与脂肪组织硬度比值高于B组、C组(P<0.05),且B组上述指标高于C组(P<0.05)。A组达峰时间(PT)短于B组、C组(P<0.05),B组PT短于C组(P<0.05)。A组增强强度高、有内部灌注缺损、增强后边界清晰占比高于B组、C组(P<0.05),且B组上述指标高于C组(P<0.05)。【结论】HER-2阳性乳腺癌患者的多模态超声特征与ER及PR的表达状态密切相关。【Objective】To investigate the multimodal ultrasound characteristics of human epidermal growth factor receptor 2(HER-2)positive breast cancer patients with different expression states of estrogen receptor(ER)and progesterone receptor(PR).【Methods】A total of 149 patients with HER-2 positive breast cancer admitted to our hospital from May 2020 to March 2024 were selected and divided into group A(n=71,positive HER-2,negative ER and PR),group B(n=27,positive HER-2,positive ER or PR)and group C(n=51,positive ER or PR)according to immunohistochemical results.HER-2,ER,PR positive.Ultrasonic characteristics of HER-2 positive breast cancer patients with different expression states of ER and PR were analyzed.【Results】The proportion of the group A with unclear boundary,enhanced posterior echo,calcification,mixed internal echo,aspect ratio>0.7,Adler grade 2-3,and BI-RADS grade 5 was higher than that of the group B and the group C(P<0.05).The above indexes in the group B were higher than those in the group C(P<0.05).The ratio of elasticity score≥3 and hardness ratio of lesion tissue to adipose tissue in the group A were higher than those in the groups B and C(P<0.05).The above indexes in group B were higher than those in the group C(P<0.05).The peak time(PT)in the group A was shorter than that in the groups B and C(P<0.05),and the PT in group B was shorter than that the in group C(P<0.05).The proportion of enhancement intensity,internal perfusion defect and clear boundary after enhancement in the group A was higher than that in the group B and the group C(P<0.05).The above indexes in group B were higher than those in group C(P<0.05).【Conclusion】The multimodal ultrasound features of patients with HER-2 positive breast cancer are closely related to the expression of ER and PR.

关 键 词:乳腺肿瘤 受体 雌激素 受体 孕酮 超声检查 受体 erbB-2 

分 类 号:R737.9[医药卫生—肿瘤]

 

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