益气活血通痹汤药浴联合甲钴胺片治疗卵巢癌化疗患者周围神经病变临床研究  

Clinical Study on Medicated Bath with Yiqi Huoxue Tongbi Decoction Combined with Mecobalamin Tablets on Chemotherapy-Induced Peripheral Neuropathy in Patients with Ovarian Cancer

作　　者：曾春英[1] 张利亚[1] ZENG Chunying;ZHANG Liya(Obstetrics and Gynecology Department,Haining Hospital of Chinese Medicine,Haining Zhejiang 314400,China)

机构地区：[1]海宁市中医院妇产科,浙江海宁314400

出　　处：《新中医》2025年第7期165-169,共5页New Chinese Medicine

基　　金：海宁市科技计划项目(2021106)。

摘　　要：目的:观察益气活血通痹汤药浴联合甲钴胺片治疗卵巢癌TC(杉醇+卡铂)方案化疗后周围神经病变(CIPN)的疗效。方法:选取2021年9月—2023年8月海宁市中医院收治的90例接受TC方案化疗且出现CIPN的卵巢癌患者,按随机数字表法分为西药组及联合组各45例。西药组给予甲钴胺片治疗,联合组在西药组基础上给予益气活血通痹汤药浴治疗。比较2组临床疗效及不良反应发生率,比较2组治疗前后周围神经毒性发生率、卡氏评分(KPS)的变化。结果:联合组临床疗效总有效率为95.56%(43/45),西药组临床疗效总有效率为82.22%(37/45),2组比较,差异有统计学意义(P<0.05)。治疗后,西药组周围神经毒性发生率为42.22%(19/45),联合组周围神经毒性发生率为15.56%(7/45),2组周围神经毒性发生率比较,差异有统计学意义(P<0.05)。治疗后,2组KPS评分均较治疗前升高(P<0.05),联合组KPS评分高于西药组(P<0.05)。西药组不良反应发生率为8.89%(4/45),联合组不良反应发生率为4.44%(2/45),2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:益气活血通痹汤药浴联合甲钴胺片能降低卵巢癌TC方案化疗后CIPN发病率,缓解症状,提高生活质量,安全性高。Objective:To observe the curative effect of medicated bath with Yiqi Huoxue Tongbi Decoction combined with Mecobalamin Tablets for chemotherapy-induced peripheral neuropathy(CIPN)in patients after TC(paclitaxel+carboplatin)regimen for ovarian cancer.Methods:A total of 90 cases of ovarian cancer patients who received TC chemotherapy and developed CIPN at Haining Hospital of Chinese Medicine from September 2021 to August 2023 were selected and randomly divided into the western medicine group and the combination group,with 45 patients in each group,according to random number table method.The western medicine group was treated with Mecobalamin Tablets,while the combination group was treated with medicated bath with Yiqi Huoxue Tongbi Decoction on the basis of the western medicine group.Compared the clinical efficacy and incidence of adverse reactions between the two groups,and compared the changes in peripheral neurotoxicity incidence and Karnofsky Performance Status(KPS)scores before and after treatment.Results:The total effective rate of clinical efficacy was 95.56%(43/45)in the combination group,and 82.22%(37/45)in the western medicine group,the difference being significant(P<0.05).After treatment,the incidence of peripheral neurotoxicity was 42.22%(19/45)in the western medicine group,and 15.56%(7/45)in the combination group,the difference being significant(P<0.05).After treatment,both groups showed an increase in KPS scores when compared with those before treatment(P<0.05),with the combination group having a higher KPS score than the western medicine group(P<0.05).The incidence of adverse reactions was 8.89%(4/45)in the western medicine group,and 4.44%(2/45)in the combination group,there being no significance in the difference(P>0.05).Conclusion:Yiqi Huoxue Tongbi Decoction combined with Mecobalamin Tablets can reduce the incidence rates of CIPN after TC chemotherapy for ovarian cancer,alleviate symptoms,improve quality of life,and have high safety.

关 键 词：卵巢癌 化疗 周围神经病变 益气活血通痹汤 甲钴胺片 药浴 

分 类 号：R737.31[医药卫生—肿瘤]