胸腔镜下肺癌根治术治疗早期非小细胞肺癌的效果及并发症发生率分析  

Effect and Complication Rate of Thoracoscopic Radical Resection of Lung Cancer in the Treatment of Early Non-small Cell Lung Cancer

作　　者：黄祖军 HUANG Zujun(Department of External Medicine Section I,Xuanwei Hospital of Traditional Chinese Medicine,Xuanwei 655400,Yunnan,China)

机构地区：[1]宣威市中医医院外一科,云南宣威655400

出　　处：《世界复合医学(中英文)》2024年第12期101-105,共5页World Journal of Complex Medicine

摘　　要：目的探讨胸腔镜下根治手术治疗早期非小细胞肺癌的效果。方法根据不同手术方式,将2023年3月—2024年1月宣威市中医医院就诊的120例早期非小细胞肺癌患者分为两组。对照组(60例)采用开胸手术治疗,观察组(60例)采取胸腔镜下肺癌根治术。对比两组围手术期指标、炎症因子指标、T淋巴细胞亚群、肿瘤微转移因子表达水平、并发症发生率。结果相较于对照组,观察组术中出血量、术后引流量、引流管留置时间、住院时间均更低,术后白细胞介素-6、C反应蛋白、血管内皮生长因子、可溶性主要组织相容性复合体Ⅰ类相关分子A、基质金属蛋白酶7 mRNA、CD8^(+)水平均更低,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均更高,差异均有统计学意义(P均<0.05)。组间手术时间、淋巴结清扫数目对比,差异均无统计学意义(P均>0.05)。观察组并发症发生率为3.33%(2/60),相比对照组的15.00%(9/60)更低,差异有统计学意义(χ^(2)=4.904,P<0.05)。结论早期非小细胞肺癌实施胸腔镜下肺癌根治术临床效果显著,且并发症发生率低。Objective To investigate the effect of thoracoscopic radical surgery in the treatment of early non-small cell lung cancer.Methods According to different surgical methods,a total of 120 patients with early non-small cell lung cancer admitted to Xuanwei Hospital of Traditional Chinese Medicine from March 2023 to January 2024 were divided into two groups.The control group(60 cases)was treated with thoracotomy,and the observation group(60 cases)was treated with thoracoscopic radical resection of lung cancer.The perioperative indicators,inflammatory factor indicators,T lymphocyte subsets,tumor micrometastasis factor expression levels and complication rates were compared between the two groups.Results Compared with the control group,the in-traoperative blood loss,postoperative drainage volume,drainage tube indwelling time and hospitalization time in the observation group were lower,the levels of interleukin-6,C-reactive protein,vascular endothelial growth factor,soluble major histocompatibility complex class I related molecule A,matrix metalloproteinase 7 mRNA and CD8^(+)after operation were lower,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)were higher,and the differences were statistically significant(all P<0.05).There were no significant difference in the operation time and the number of lymph node dissection between the two groups(both P>0.05).The incidence of complications in the observation group was 3.33%(2/60),which was lower than 15.00%(9/60)in the control group,and the differ-ence was statistically significant(χ^(2)=4.904,P<0.05).Conclusion The clinical effect of thoracoscopic radical re-section of lung cancer in early non-small cell lung cancer is significant,and the incidence of complications is low.

关 键 词：早期非小细胞肺癌 胸腔镜下肺癌根治术 手术效果 并发症 

分 类 号：R734.2[医药卫生—肿瘤]