基于“亢害承制”理论探讨2型糖尿病胰岛β细胞的去分化与再分化及解毒化浊法的干预作用  

A Study on Dedifferentiation and Redifferentiation of Pancreatic β-cells in Type-Ⅱ Diabetes,and the Interventional Effect of the Detoxifying and Resolving Turbidity Method Based on the Theory of"Restraining Excessiveness to Acquire Harmony"

作　　者：卿菁 赵伟 吴春红 孙庆 QING Jing;ZHAO Wei;WU Chunhong;SUN Qing(Guizhou University of Traditional Chinese Medicine,Guiyang 550025,Guizhou,China;The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550003,Guizhou,China)

机构地区：[1]贵州中医药大学,贵州贵阳550025 [2]贵州中医药大学第二附属医院,贵州贵阳550003

出　　处：《贵州中医药大学学报》2025年第2期1-5,共5页Journal of Guizhou University of Traditional Chinese Medicine

基　　金：国家自然科学基金地区科学基金项目(82260875);贵州中医药大学院内课题(YCXKYS2023023)。

摘　　要：“亢害承制”理论是中医理论体系的重要基石,本文从“亢害承制”理论探析糖、脂毒性与胰岛β细胞去分化之间“亢而失制则成害”及胰岛β细胞再分化之间“制其亢,除其害”的关系,并基于浊毒理论探讨解毒化浊法对胰岛β细胞去分化及再分化的干预作用,提出了运用解毒化浊法以“平其所亢”及“承而制之”的胰岛β细胞保护方法。The theory"restraining excessiveness to acquire harmony"is an important cornerstone of the theoretical system of traditional Chinese medicine.This article discussed the relationship of"uncontrolled excessiveness becoming harmful"between glycotoxicity,lipid toxicity and islet β cell dedifferentiation,and the relationship of"preventing its excess and eliminating its harm"between islet β cell redifferentiation based on the theory of"restraining excessiveness to acquire harmony".Based on the turbid toxin theory,the interventional effect of the method of detoxifying and resolving turbidity on β-cell dedifferentiation and redifferentiation is also investigated in this article.A β-cell protection approach utilizing the method of detoxifying and resolving turbidity is proposed,aiming to"balance its excess"and"restrain it through counteraction",thereby safeguarding the islet β-cells.

关 键 词：亢害承制 胰岛Β细胞 去分化与再分化 解毒化浊法 浊毒理论 

分 类 号：R226[医药卫生—中医基础理论] R587.1[医药卫生—中医学]