Biomaterials science and surface engineering strategies for dental peri‑implantitis management  

作　　者：Ya-Meng Yu Yu-Pu Lu Ting Zhang Yu-Feng Zheng Yun-Song Liu Dan-Dan Xia 

机构地区：[1]Department of Dental Materials,Peking University School and Hospital of Stomatology,Beijing 100081,China [2]National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices,Beijing Key Laboratory of Digital Stomatology&NHC Key Laboratory of Digital Stomatology&NMPA Key Laboratory for Dental Materials,Beijing 100081,China [3]School of Materials Science and Engineering,Peking University,Beijing 100871,China [4]Department of Prosthodontics,Peking University School and Hospital of Stomatology,Beijing 100081,China.

出　　处：《Military Medical Research》2025年第3期354-392,共39页军事医学研究(英文版)

基　　金：supported by the National Key Research and Development Program of China(2023YFC2412600);the National Natural Science Foundation of China(52271243,52171233,82370924,82170929);the Beijing Natural Science Foundation(L212014);the Beijing Nova Program(20230484459);the National Clinical Key Discipline Construction Project(PKUSSNKP-T202103);the Research Foundation of Peking University School and Hospital of Stomatology(PKSS20230104).

摘　　要：Peri-implantitis is a bacterial infection that causes soft tissue inflammatory lesions and alveolar bone resorption,ultimately resulting in implant failure.Dental implants for clinical use barely have antibacterial properties,and bacterial colonization and biofilm formation on the dental implants are major causes of peri-implantitis.Treatment strategies such as mechanical debridement and antibiotic therapy have been used to remove dental plaque.However,it is particularly important to prevent the occurrence of peri-implantitis rather than treatment.Therefore,the current research spot has focused on improving the antibacterial properties of dental implants,such as the construction of specific micro-nano surface texture,the introduction of diverse functional coatings,or the application of materials with intrinsic antibacterial properties.The aforementioned antibacterial surfaces can be incorporated with bioactive molecules,metallic nanoparticles,or other functional components to further enhance the osteogenic properties and accelerate the healing process.In this review,we summarize the recent developments in biomaterial science and the modification strategies applied to dental implants to inhibit biofilm formation and facilitate bone-implant integration.Furthermore,we summarized the obstacles existing in the process of laboratory research to reach the clinic products,and propose corresponding directions for future developments and research perspectives,so that to provide insights into the rational design and construction of dental implants with the aim to balance antibacterial efficacy,biological safety,and osteogenic property.

关 键 词：PERI-IMPLANTITIS Dental implant Osteogenic property Antibacterial activity Anaerobic bacteria 

分 类 号：R783.6[医药卫生—口腔医学]