ADP‑dependent glucokinase:the ancient,archaeal key to prostate cancer  

作　　者：Marcin M.Kamiński 

机构地区：[1]Department of Immunology,St.Jude Children’s Research Hospital,Memphis,TN 38105,USA

出　　处：《Military Medical Research》2025年第3期467-468,共2页军事医学研究(英文版)

摘　　要：The December 2023 issue of the Military Medical Research brings out an astounding discover y by Xu et al.[1]demonstrating a key role of the mysterious enzyme ADPdependent glucokinase(ADPGK)in the cellular metabolism of prostate cancer(PCa).The ADPGKs are enzymes typically found in thermophilic archaea where they mediate the indispensable,first step of glucose metabolism,i.e.phosphorylation of glucose to glucose-6-phosphate.Strikingly,ADPGKs utilize ADP as a phosphate donor instead of ATP typically used to initiate glycolysis by four“classical”eukaryotic hexokinases(HKⅠ–Ⅲand glucokinase).Thus,the discovery made by Ronimus and Morgan[2]of the functional form of ADPGK in mice,opened an intriguing question of the specific role of this enzyme in the metabolism of eukaryotic cell.

关 键 词：ADP-dependent glucokinase(ADPGK) Prostate cancer Prognostic marker ADENOCARCINOMA AMPactivated protein kinase(AMPK) Aldolase C(ALDOC) 

分 类 号：R737.25[医药卫生—肿瘤]