The Spatial Location of Chromosomes in Dividing Cells and the Relative Stability of Chromosome Spatial Structure  

作　　者：Chunxiao Wu Dongyun Jiang Tao Jiang Luxia Xu Qian Xu Meng Zhao Qin Zhu ZhigangGuo Jinlan Pan Suning Chen 

机构地区：[1]Jiangsu Institute of Hematology,National Clinical Research Center for Hematologic Diseases,NHC Key Laboratory of Thrombosis and Hemostasis,The First Affiliated Hospital of Soochow University,Suzhou 215008,Jiangsu Province,China [2]The Second Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210000,Jiangsu Province,China [3]Jiangsu Key Laboratory for Molecular and Medical Biotechnology,College of Life Sciences,Nanjing Normal University,Nanjing 210000,Jiangsu Province,China [4]The Second Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Second Chinese Medicine Hospital,Nanjing 210000,Jiangsu Province,China [5]Department of Epidemiology and Health Statistics,School of Public Health,Southeast University,Nanjing 210000,Jiangsu Province,China [6]Experiment Center for Science and Technology,Nanjing University of Chinese Medicine,Nanjing 210000,Jiangsu Province,China

出　　处：《Proceedings of Anticancer Research》2025年第2期83-91,共9页抗癌研究

摘　　要：The stability and evolution of human genetics depend on chromosomes and chromosome-chromosome interactions.We wish to understand the spatial location of chromosomes in dividing cells in order to understand the relationship between chromosome-chromosome interactions and to further investigate the role of chromosomes and their impact on cell biological behavior.In this study,we explored the relative spatial positional relationships of chromosomes[t(9;22)and t(15;17)]in B-ALL cells by using the three-dimensional DNA fluorescent in situ hybridization(3D-FISH)method.The results showed that chromosomes[t(9;22)and t(15;17)]showed relatively stable spatial relationships.The relative stability of the spatial location of chromosomes in dividing cells may be relevant to disease.

关 键 词：CHROMOSOME Human genetics Chromosome territory 3D-FISH 

分 类 号：R73[医药卫生—肿瘤]