肿瘤浸润免疫细胞CD38表达对淋巴结转移食管鳞状细胞癌预后的影响  

Effect of CD38 expression of tumor-infiltrating immune cells on the prognosis of esophageal squamous cell carcinoma with lymph node metastasis

作　　者：石峰 赵艳杰 高颖 宋清坤 Shi Feng;ZhaoYanjie;Gao Ying;Song Qingkun(Department of Pathology,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China;Department of Medical Oncology,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China;Department of Biomedical Information Center,Beijing Youan Hospital,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学附属北京世纪坛医院病理科,北京100038 [2]首都医科大学附属北京世纪坛医院肿瘤内科,北京100038 [3]首都医科大学附属北京佑安医院生物医学信息中心,北京100069

出　　处：《首都医科大学学报》2025年第2期210-215,共6页Journal of Capital Medical University

基　　金：北京市属医院科研培育项目(PX2021031)。

摘　　要：目的探讨CD38对食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)肿瘤免疫微环境及临床病理的影响。方法对2015年至2018年在首都医科大学附属北京世纪坛医院进行食管切除术的142例ESCC患者进行了回顾性队列研究。评估患者的临床病理特征、肿瘤组织内CD38、CD4、CD8、Ki-67、程序性细胞死亡配体1(programmed cell death ligand 1,PD-L1)和程序性细胞死亡受体1(programmed cell death 1,PD-1)的表达情况。结果在有淋巴结转移的ESCC患者中,CD38的表达率与总生存期有显著相关性(P=0.037),低表达组和高表达组患者的中位生存期分别为14个月和38个月。未经调整和调整的高CD38表达风险比分别为0.46(95%CI:0.21~0.98)和0.32(95%CI:0.13~0.76)。CD38的表达率与肿瘤细胞PD-L1表达呈负相关。结论对于有淋巴结转移的ESCC患者来说,CD38高表达与更好的生存率相关。Objective To investigate the prognostic effect of CD38 in patients with esophageal squamous cell carcinoma patients(ESCC).Methods A retrospective cohort study with 142 ESCC patients was performed.The clinicopathological features and expression of CD38,CD4,CD8,Ki-67,programmed cell death ligand 1(PD-L1)and programmed cell death 1(PD-1)in tumor and immune cells were evaluated.Results Among ESCC patients with lymph node metastasis,the expression of CD38 had a significant association with the overall survival(P=0.037).The median overall survival was 14 months and 38 months among patients with low and high expression of CD38,respectively.The crude and adjusted hazard ratio of high CD38 expression was 0.46(95%CI:0.21-0.98)and 0.32(95%CI:0.13-0.76)respectively.The expression of CD38 had a negative correlation with PD-L1 expressed in tumor cells.Conclusion The high expression of CD38 was associated with a better survival for ESCC with lymph node metastasis.

关 键 词：食管鳞状细胞癌 CD38 肿瘤浸润免疫细胞 免疫微环境 程序性细胞死亡配体1 

分 类 号：R735[医药卫生—肿瘤]