基于多肽水凝胶制备及表征为例的前沿科技成果融入医用有机化学实验教学实践  

Application of Frontier Scientific and Technological Achievements Based on Preparation and Characterization of Polypeptide Hydrogel in Teaching Practice of Medical Organic Chemistry Experiment

作　　者：殷超 古丽巴哈尔·卡吾力[1] 依明·尕哈甫[1] 陈凤霞 陈荣玲 马晓艺 YIN Chao;GULBAHAR Kawuli;YIMING Wagafu;CHEN Fengxia;CHEN Rongling;MA Xiaoyi(College of Pharmacy,Xinjiang Medical University,Xinjiang Urumuqi 830000,China)

机构地区：[1]新疆医科大学药学院,新疆乌鲁木齐830000

出　　处：《广州化工》2025年第6期207-211,共5页GuangZhou Chemical Industry

基　　金：国家级一流专业(药学)。

摘　　要：以羧甲基壳聚糖与泊洛沙姆F127为原料,以乙二醛为交联剂制备了用于多肽递送的水凝胶载体。研究了多肽水凝胶形成机理与性能。通过多肽水凝胶的制备可以帮助学生巩固理论课中所学多糖与肽章节中所学的知识点,将理论与实际相结合,帮学生更好的掌握所学理论知识内容。此外,此次实验结合医工交叉优势,可帮助学生初步构建系统的科研体系,激发学生科研兴趣,为医用有机化学实验教学改革提供参考的同时为学生科研之路奠定基础。Carboxymethyl chitosan and poloxamer F127 were used as raw materials,and glyoxal was used as crosslinking agent to prepare hydrogel carrier for peptide delivery.The formation mechanism and properties of polypeptide hydrogel were studied.The preparation of polypeptide hydrogel can help students consolidate the knowledge points learned in the chapter of polysaccharide and peptide in the theoretical lesson.It was the combination of theory and practice to help students better master the theoretical knowledge.In addition,this experiment combined the advantages of medical engineering intersection,which can help students initially construct a systematic scientific research system,stimulate their interest in scientific research,provide reference for the reform of Medical Organic Chemistry experiment teaching,and lay a foundation for students´scientific research path.

关 键 词：天然多糖 肽 水凝胶 科研成果 实验教学 

分 类 号：TQ469[化学工程—制药化工]