HIF-1α在糖尿病肾病中的机制研究及中医药改善作用的研究进展  

Mechanism of HIF-1αin Diabetic Nephropathy and Improvement Effect of Traditional Chinese Medicine:A Review

作　　者：谢家润 林浩裕 陈茜 孙嘉[2] 王明[1,2] XIE Jiarun;LIN Haoyu;CHEN Xi;SUN Jia;WANG Ming(School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China;Zhujiang Hospital of Southern Medical University,Guangzhou 510280,China)

机构地区：[1]南方医科大学中医药学院,广州510515 [2]南方医科大学珠江医院,广州510280

出　　处：《中国实验方剂学杂志》2025年第8期287-293,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(82074207,82374271);广东省自然科学基金项目(2023A1515012539);大学生创新创业训练计划项目(S202312121198)。

摘　　要：近年来,糖尿病肾病(DN)已成为全球范围内一个日益严峻的健康挑战,其发病率与死亡率正迅速攀升,且患者年龄渐趋于年轻化。DN不仅伴随着广泛的肾脏病理改变,如肾脏肥大、炎症细胞浸润、系膜基质扩张及基底膜增厚等,更是导致糖尿病患者发生终末期肾病和死亡的主要原因,因此,探索DN的预防与治疗新策略显得尤为迫切。DN的发病机制错综复杂,当前研究多聚焦于代谢与血流动力学因素等多因素相互作用,诸如缺氧、炎症反应及纤维化过程等。值得注意的是,缺氧在DN的启动与进展中扮演着举足轻重的角色。缺氧诱导因子-1α(HIF-1α),作为一种在缺氧细胞中普遍存在的关键调节蛋白,对细胞代谢、血管新生、氧化应激反应及细胞凋亡等多个生理病理过程具有深远影响。而中医药以其独特的理论体系与治疗方法,在应对缺氧性疾病方面展现出了显著优势,能通过调节HIF-1α及其下游信号分子的表达水平,发挥抗炎、抗氧化和抗纤维化的作用,延缓DN的进展,对于药物研发和DN的早期防治具有积极的临床意义。In recent years,diabetic nephropathy(DN)has become an increasingly serious health challenge worldwide,and its morbidity and mortality rates are rapidly increasing.The patients suffering from the disease tend to be younger.DN is not only accompanied by a wide range of renal pathological changes,such as renal hypertrophy,inflammatory cell infiltration,expansion of the tethered membrane stroma,and thickening of the basement membrane but is also the main cause of end-stage renal disease and death in patients with diabetes mellitus.Therefore,it is particularly urgent to explore new strategies for the prevention and treatment of DN.The pathogenesis of DN is intricate and complex,with current research focusing on multifactorial interactions between metabolic and hemodynamic factors,such as hypoxia,inflammatory responses,and fibrotic processes.Notably,hypoxia plays a pivotal role in the initiation and progression of DN.Hypoxia-inducible factor(HIF-1α),as a key regulatory protein commonly found in hypoxic cells,has a profound impact on various physiological and pathological processes,such as cell metabolism,vascular neogenesis,oxidative stress,and apoptosis.With its unique theoretical system and therapeutic approach,traditional Chinese medicine has demonstrated significant advantages in coping with hypoxic diseases and can slow down the progression of DN by regulating the expression level of HIF-1αand its downstream signaling molecules and exerting anti-inflammatory,antioxidant,and antifibrotic effects,which has positive clinical significance for drug development and early prevention and treatment of DN.

关 键 词：糖尿病肾病 缺氧 缺氧诱导因子-1Α 代谢调节 中医药 

分 类 号：R242[医药卫生—中医临床基础] R282[医药卫生—中医学] R259