肠道菌群与格雷夫斯眼病相关性的研究进展  

The research progress on the correlation between gut microbiota and Graves'ophthalmopathy

作　　者：李悦颖 袁善思 汪洋 李凯军[1] Li Yue-Ying;Yuan Shan-Si;Wang Yang;Li Kai-Jun(Department of Ophthalmology,the First Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi 530021,China)

机构地区：[1]广西医科大学第一附属医院眼科,广西南宁530021

出　　处：《解放军医学杂志》2025年第3期269-276,共8页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金(82160206);广西自然科学基金(2018GXNSFAA281234)。

摘　　要：格雷夫斯眼病(GO)是一种发生在眼眶组织的特异性自身免疫性疾病,与格雷夫斯病(GD)所致的甲状腺功能亢进症密切相关;其致残及毁容性严重影响患者的生活质量。GO的确切机制仍有待充分阐明。近年来,基因测序及医学微生物学研究显示,肠道菌群的改变可能在GO发生发展中发挥作用,肠道生态失调可改变免疫系统的调节信号,造成器官的免疫损害。明确肠道菌群与GO的相关性有助于了解疾病的致病机制,为GO的诊疗提供理论依据。本文综述肠道菌群失调在GO发病过程中的影响及有前景的相关治疗方法,包括肠道菌群实验、病例研究及发病机制和治疗等方面的研究进展。Graves'ophthalmopathy(GO)is a specific autoimmune disease occurring in orbital tissues and is closely related to hyperthyroidism caused by Graves'disease(GD).Its disabling and disfiguring features significantly impact the quality of life of patients.The exact mechanism of GO still remains to be fully elucidated.In recent years,gene sequencing and medical microbiology studies have shown that changes in the gut microbiota may play a role in the development and progression of GO,with gut dysbiosis altering immune system regulatory signals and causing immune damage to organs.Clarifying the correlation between gut microbiota and GO helps to understand the disease's pathogenic mechanism and provides a theoretical basis for the diagnosis and treatment of GO.This review summarizes the impact of gut microbiota dysbiosis in the pathogenesis of GO and promising therapeutic approaches,including research progress in aspects such as gut microbiota experiments,case studies,pathogenesis,and treatment strategies.

关 键 词：格雷夫斯眼病 肠道菌群 发病机制 治疗 

分 类 号：R771.3[医药卫生—眼科] R581.1[医药卫生—临床医学]