益生菌辅助根除幽门螺杆菌的研究进展  

Probiotic-assisted eradication of Helicobacter pylori infection:research progress

作　　者：康晋 郭俊芝 KANG Jin;GUO Junzhi(The First Clinical Medical College of Shanxi Medical University,Taiyuan,Shanxi 030001,China;不详)

机构地区：[1]山西医科大学第一临床医学院,山西太原030001 [2]山西医科大学第一医院

出　　处：《中国微生态学杂志》2025年第2期245-248,F0003,共5页Chinese Journal of Microecology

摘　　要：幽门螺杆菌(Helicobacter pylori,H.pylori)已被世界卫生组织确定为胃癌的主要致病因素,与浅表性胃炎、萎缩性胃炎和胃癌密切相关。由于现有的H.pylori根除方案中抗生素耐药性和胃肠道不良反应的增加,使得H.pylori感染的根除率持续下降,难以达到预期的效果。大量的临床试验和荟萃分析表明,益生菌与标准三联、铋剂四联或高剂量二联联合可提高H.pylori根除率,并减少头痛、腹泻、恶心和呕吐等不良事件的发生。然而,还需要进一步的研究来确定益生菌的类型、剂量、持续时间、添加时机(治疗前、治疗中或治疗后)、安全性、适用人群和成本效益等。Helicobacter pylori(H.pylori)has been identified by the World Health Organization as the main pathogenic factor of gastric cancer,and is associated closely with superficial gastritis,atrophic gastritis and gastric cancer.Due to the increased resistance to antibiotics and gastrointestinal side effects in existing H.pylori eradication regimens,the eradication rate of H.pylori has continuously decreased,making it difficult to achieve the desired effect.Numerous clinical trials and meta-analyses have shown that probiotics in combination with standard triple,bismuth quadruple or high-dose double combination therapies can improve the H.pylori eradication rate and reduce the occurrence of adverse events such as headache,diarrhea,nausea and vomiting.However,further studies are needed to determine the type,dose,duration,timing of addition(pre-,during or post-treatment),safety,applicable population,and cost-effectiveness of probiotics.

关 键 词：幽门螺杆菌 益生菌 根除治疗 

分 类 号：R573.3[医药卫生—消化系统]