基底细胞黏附分子作为癌症治疗靶点的研究进展  

Research Progress of Basal Cell Adhesion Molecules as Cancer Therapeutic Targets

作　　者：曹敏[1,2] 叶慧 李文蕾[2] 李剑 黄瑞晶 CAO Min;YE Hui;LI Wen-lei;LI Jian;HUANG Ruijing(Stater Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing 210000,China;Tasly Pharmaceutical Group Co.,Ltd.,Tianjin 300000,China)

机构地区：[1]中国药科大学多靶标天然药物全国重点实验室,江苏南京210000 [2]天士力医药集团股份有限公司,天津300000

出　　处：《药物生物技术》2025年第1期97-103,共7页Pharmaceutical Biotechnology

摘　　要：基底细胞黏附分子是一种跨膜糖蛋白,在人类多种实体肿瘤中表达,且与肿瘤进展和转移相关的生物学过程有关,包括细胞的黏附、运动、迁移和侵袭。在不同类型的癌症中,基底细胞黏附分子显示出致癌或抑癌的作用,可被用作癌症生物标志物和治疗目标。文章旨在综述基底细胞黏附分子在癌症研究和靶向治疗方面的最新进展,为其开发癌症治疗策略提供新思路。Compared with traditional chemotherapy,radiotherapy and other cancer treatments,targeted drug therapy interferes with specific targets to prevent the proliferation,growth and metastasis of tumor cells without damaging normal cells.Target selection is the key and core of targeted therapy,so it is of great practical significance and clinical value to screen out new,effective and safe tumor treatment targets.Basal cell adhesion molecules are transmembrane glycoproteins that are widely expressed in epithelial cells,endothelial cells,hematopoietic cells,and other types of cells.As cell adhesion molecules,they are expressed in a variety of human solid tumors and are associated with biological processes related to tumor progression and metastasis.And in different types of cancer,basal cell adhesion molecules show carcinogenic or cancer-suppressive effects,so they can be used as cancer biomarkers and therapeutic targets.This article aims to review the signaling pathways of basal cell adhesion molecules and their targeted therapeutic effects on different tumor cells,mainly from the perspective of tumor cell proliferation,metastasis and invasion,and put forward development ideas combined with target characteristics,in order to open up new ways for cancer therapy.

关 键 词：细胞黏附分子 基底细胞黏附分子 癌症研究 癌症治疗靶点 肿瘤靶向治疗 靶点开发 

分 类 号：R730.5[医药卫生—肿瘤]