m6A甲基化修饰在肝纤维化中的研究进展  

Research on the Role of m6A Methylation in Liver Fibrosis

作　　者：黎燕珊 王淑珍[1] LI Yanshan;WANG Shuzhen(School of Life Science and Technology,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学生命科学与技术学院,江苏南京211198

出　　处：《药物生物技术》2025年第1期104-108,共5页Pharmaceutical Biotechnology

摘　　要：m6A甲基化修饰是真核生物中普遍存在且高度保守的mRNA转录后修饰,指mRNA上腺嘌呤6位上的氨基发生甲基化修饰的过程。m6A甲基化修饰反应是可逆的,相关调控因子包括甲基化转移酶、去甲基化酶和甲基化阅读蛋白。其中,甲基化转移酶催化m6A甲基化修饰的发生,去甲基化酶负责去除m6A甲基化修饰,甲基化阅读蛋白负责特异性识别m6A甲基化修饰基序。m6A甲基化修饰可通过影响mRNA的剪切、成熟、核输出、翻译、降解、稳定性等生物学过程,在各种生理和病理条件下发挥关键作用。肝纤维化是慢性肝炎发展到肝硬化甚至肝癌的关键一步,且其被证明是可逆转的。然而,目前临床上尚未找到能治愈肝纤维化的有效方法,严重影响患者的健康和生活质量,加重患者医疗负担。已有较多的证据表明,m6A调控因子的异常表达或功能异常与肝纤维化的发生和进展相关。本文围绕m6A甲基化修饰作用机制及其调控因子在肝纤维化中的最新研究进展进行综述,旨在为肝纤维化逆转研究提供新的思路和依据。m6A(N6-methyladenosine)methylation is a highly conserved post-transcriptional modification of mRNA that is commonly found in eukaryotes,referring to the methylation modification of the amino group at position 6 of adenine in mRNA.Moreover,m6A methylation has been demonstrated to be reversibly regulated by methyltransferases(writers),demethylases(erasers)and m6A binding proteins(readers).Among them,methyltransferases catalyze the occurrence of m6A methylation modifications through enzymatic reactions;Demethylases are responsible for removing m6A methylation modifications;And m6A binding proteins are responsible for specifically recognizing the motifs of m6A methylation modifications.It is widely known that m6A methylation plays crucial roles in various physiological and pathological conditions by influencing biological processes such as mRNA splicing,export,translation,decay,and stability.Furthermore,liver fibrosis is a crucial stage in the progression from chronic hepatitis to cirrhosis and even liver cancer,and it can further develop into cirrhosis or liver cancer in the absence of treatment.It is noteworthy that when the cause of liver fibrosis is removed or controlled,the process of liver fibrosis can be delayed or even reversed.However,there is currently no effective method to cure liver fibrosis in clinical practice,and its serious complications pose a significant threat to the health and life quality of patients,resulting in a heavy medical burden.It is urgent to find effective means to reverse liver fibrosis.Meanwhile,an increasing number of studies have indicated that the abnormal expression or function of m6A regulators is related to the occurrence and progression of liver fibrosis,suggesting that conducting in-depth research on the role of m6A methylation in liver fibrosis can provide effective strategies for reversing liver fibrosis.This article reviews the latest research on the mechanism of m6A methylation and its regulators in liver fibrosis,aiming to provide new ideas and a basis for the study of l

关 键 词：肝纤维化 RNA修饰 m6A甲基化 调控因子 甲基化转移酶 去甲基化酶 甲基化阅读蛋白 

分 类 号：R575.2[医药卫生—消化系统]