乳腺乳头状肿瘤临床病理及分子遗传学研究进展  

Advances in the clinicopathology and molecular genetic changes of papillary breast tumors

作　　者：候智辉 李丽[1,2] Hou Zhihui;Li Li(Department of Pathology,Qilu Hospital of Shandong University,Jinan 250012,China;Department of Pathology,School of Basic Medical Sciences,Shandong University,Jinan 250012,China)

机构地区：[1]山东大学齐鲁医院病理科,济南250012 [2]山东大学基础医学院病理学系,济南250012

出　　处：《临床与实验病理学杂志》2025年第3期374-379,共6页Chinese Journal of Clinical and Experimental Pathology

摘　　要：乳腺乳头状肿瘤是以上皮增生并形成含有纤维血管轴心的乳头状结构为特征的一组异质性肿瘤,其重叠的形态学和免疫表型给病理诊断带来巨大挑战。乳头状肿瘤的诊断与预后一直是学者们讨论的焦点,分子遗传学研究揭示各组织学亚型的遗传异质性,并发现各亚型中独特的分子变异特征。该文对乳腺乳头状肿瘤的临床病理特征及分子遗传学进展进行综述。Papillary neoplasms of breast are a group of heterogenous tumors characterized by epithelial hyperplasia and the formation of papillary structures containing fibrovascular axes.Their overlapping morphological and immunophenotypes pose a major challenge to pathological diagnosis,so the diagnosis and prognosis of papillary tumors have been the focus of debate.Furthermore,the use of molecular assays has revealed the genetic heterogeneity of the histological subtypes and identified unique molecular variant features in each subtype.This article reviews the molecular genetic developments and clinicopathological characteristics of papillary breast tumors.

关 键 词：乳腺肿瘤 乳头状肿瘤 病理特点 分子特征 文献综述 

分 类 号：R737.9[医药卫生—肿瘤]