重性抑郁障碍患者快感缺失与免疫炎症因子的相关性分析  

Correlation analysis of anhedonia and immune inflammatory factors in patients with major depressive disorder

作　　者：郝卓群 王根维 杜巧荣[1] 李国娟 聂佳慧 刘鹏鸿[1] 王彦芳[1] HAO Zhuoqun;WANG Genwei;DU Qiaorong(First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一医院,山西太原030001 [2]山西医科大学第一临床医学院 [3]山西医科大学基础医学院 [4]山西医科大学人文与社会科学学院

出　　处：《精神医学杂志》2024年第6期585-589,共5页Journal of Psychiatry

基　　金：国家重点研发项目(编号:2016YFC1307103);山西省卫生健康委科研基金项目(编号:2022140);山西省136兴医工程项目(编号:Y2022136012)。

摘　　要：目的探讨重性抑郁障碍(MDD)患者快感缺失与免疫炎症因子的相关性。方法选取71例首发未治疗的MDD患者和同期社区招募的31名健康对照(对照组)作为研究对象。根据快感缺失症状标准以及斯奈思-汉密尔顿快感量表(SHAPS)评分将首发MDD患者分为伴有快感缺失特征的MDD组40例和不伴有快感缺失特征的MDD组31例,比较三组受试者血清白细胞介素(IL)-6、IL-10、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)水平,分析SHAPS评分、汉密尔顿抑郁量表(HAMD-17)总分与免疫炎症因子的相关性。结果三组间HAMD-17评分及免疫炎症因子IL-6、IL-10、TNF-α、hs-CRP的水平比较,差异均有统计学意义(P<0.05)。进一步的两两比较结果显示,伴有快感缺失特征的MDD组与不伴快感缺失特征的MDD组HAMD-17评分、IL-6、IL-10、TNF-α、hs-CRP水平均高于对照组(P<0.05);伴有快感缺失特征的MDD组IL-6水平高于不伴有快感缺失特征的MDD组(P<0.05),IL-10水平低于不伴有快感缺失特征的MDD组(P<0.05)。MDD患者IL-6、TNF-α水平与SHAPS评分均呈正相关(P<0.05),MDD患者的IL-10水平与SHAPS评分呈负相关(P<0.05);MDD患者IL-6、IL-10、TNF-α、hs-CRP水平与HAMD-17评分均呈正相关(P<0.001)。结论血清IL-6、IL-10水平可能作为区分伴/不伴有快感缺失特征的MDD患者的生物标志物,MDD患者快感缺失症状的严重程度可能与血清IL-6、IL-10、TNF-α水平有关。Objective To explore the correlation between anhedonia and immune inflammatory factors in patients with major depressive disorder(MDD).Methods A total of 71 untreated patients with first-episode MDD,along with 31 healthy controls(control group)were selected.Based on the criteria of anhedonia and Snaith-Hamilton Pleasure Scale(SHAPS)scores,the first-episode MDD patients were divided into MDD with anhedonia group(40 cases)and MDD without anhedonia group(31 cases).The levels of interleukin-6(IL-6),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP)were compared among the 3 groups.The relationships between 17-Item Hamilton Depression Scale(HAMD-17)score,SHAPS score and immune-inflammatory factors were analyzed.Results There existed significant differences in HAMD-17 scores,levels of IL-6,IL-10,TNF-α,and hs-CRP among three groups(P<0.05).Compared with control group,both MDD with anhedonia group and MDD without anhedonia group had higher HAMD-17 scores,and elevated serum levels of IL-6,IL-10,TNF-α,and hs-CRP(P<0.05).MDD with anhedonia group had higher serum level of IL-6(P<0.05)and lower serum level of IL-10(P<0.05)than MDD without anhedonia group.The total score of HAMD-17 was positively correlated with the serum levels of IL-6,IL-10,TNF-αand hs-CRP among MDD patients(P<0.001).SHAPS score was positively correlated with the serum levels of IL-6 and TNF-α(P<0.05)and negatively correlated with the serum levels of IL-10 among MDD patients(P<0.05).Conclusion Serum levels of IL-6 and IL-10 may serve as biomarkers to distinguish MDD with anhedonia or MDD without anhedonia.The severity of anhedonic symptoms in MDD may be associated with the serum levels of IL-6,IL-10 and TNF-α.

关 键 词：免疫炎症因子 重性抑郁障碍 快感缺失 

分 类 号：R749.4[医药卫生—神经病学与精神病学]