曲唑酮及艾司西酞普兰对抑郁症患者性功能及男性性激素水平的影响  

Effects of trazodone and escitalopram on sexual function and androgen level in depressed patients

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作  者:姜珊 马一鸣 王志飞 马家惠 赵明明 刘增训[2] JIANG Shan;MA Yiming;WANG Zhifei(Mental Health College,Jining Medical University,Jining 272067,China)

机构地区:[1]济宁医学院精神卫生学院,山东济宁272067 [2]山东省精神卫生中心(山东大学附属精神卫生中心)

出  处:《精神医学杂志》2024年第6期590-594,共5页Journal of Psychiatry

基  金:国家自然科学基金项目(编号:81871044)。

摘  要:目的探究曲唑酮及艾司西酞普兰对抑郁症患者疗效、性功能及男性性激素水平的影响。方法选取116例抑郁症患者,采用随机数字表法将患者分为研究组(曲唑酮治疗)与对照组(艾司西酞普兰治疗),两组各58例患者完成6周的研究。比较两组治疗前后的17项汉密尔顿抑郁量表(HAMD-17)、亚利桑那性体验量表(ASEX)、国际勃起功能指数问卷(IIEF-5)及男性患者性激素水平。对研究组男性患者的睾酮激素水平与ASEX及IIEF-5评分进行相关性分析。结果两组治疗后第2、4、6周末,HAMD-17评分均较治疗前降低(P<0.01)。研究组治疗后第2、4、6周末,ASEX评分均较治疗前降低(P<0.01);对照组治疗后第4、6周末,ASEX评分均较治疗前升高(P<0.01)。研究组治疗后第4、6周末,ASEX评分低于对照组(P<0.001)。治疗后第6周末,研究组男性患者IIEF-5评分较治疗前升高(P<0.01),且高于对照组(P<0.001)。治疗后第2周末,对照组男性患者LH、FSH水平较治疗前降低(P<0.05);治疗后第4、6周末,研究组男性患者Testo水平较治疗前升高(P<0.01),同时研究组Testo水平高于对照组(P<0.05)。治疗前研究组Testo水平与IIEF-5评分呈正相关(P<0.05);治疗后第2、6周末,Testo水平与ASEX评分均呈负相关(P<0.05);治疗后第6周末,Testo水平与IIEF-5评分呈正相关(P<0.05)。结论曲唑酮与艾司西酞普兰抗抑郁疗效相当,但二者对性功能影响有所差异,曲唑酮改善性功能水平更佳,并可提高男性抑郁症患者睾酮激素水平。Objective To explore the effects of trazodone and escitalopram on efficacy,sexual function and androgen level in patients with depression.Methods A total of 116 patients with depression were selected and randomly divided into study group(58 cases)treated with trazodone and control group(58 cases)treated with escitalopram for 6 weeks.The scores of 17-item Hamilton Depression Scale(HAMD-17),Arizona Sexual Experience Scale(ASEX),International Index of Erectile Function(IIEF-5),and the androgen levels in male patients before and after the treatment were compared in both groups.In male patients of study group,a correlation analysis was conducted between testosterone level and scores of ASEX and IIEF-5.Results At the ends of the 2^(nd),4^(th) and 6^(th) weeks after treatment,the scores of HAMD-17 in both groups decreased compared with those before treatment(P<0.01);ASEX scores in study group decreased compared with that before treatment(P<0.01).At the ends of the 4^(th) and 6^(th) weeks after treatment,ASEX scores in control group increased compared with that before treatment(P<0.01);and ASEX scores in study group were lower than those in control group(P<0.001).At the end of the 6th week after treatment,IIEF-5 score in male patients of study group increased compared with that before treatment(P<0.01),and was higher than that in control group(P<0.001).At the end of the 2^(nd) week after treatment,the levels of LH and FSH in control group decreased compared with those before treatment(P<0.05).At the ends of the 4^(th) and 6^(th) weeks after treatment,the Testo levels in study group increased compared with that before treatment(P<0.01),and were higher than those in control group(P<0.05).A correlation analysis revealed that pre-treatment Testo level was positively correlated with the IIEF-5 score(P<0.05)and negatively correlated with ASEX scores at the ends of the 2^(nd) and 6^(th) weeks after treatment(P<0.05).At the end of the 6^(th) week,Testo level was positively correlated with IIEF-5 score(P<0.05).Conclusion The anti

关 键 词:抑郁症 性功能障碍 曲唑酮 艾司西酞普兰 性激素 

分 类 号:R749.4[医药卫生—神经病学与精神病学]

 

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