曲克芦丁脑蛋白水解物联合尼麦角林对急性缺血性脑卒中患者的影响  

Effects of troxrutin brain protein hydrolysate combined with Niergoline in patients with acute ischemic stroke

作　　者：陈灵聪 张媛 CHEN Lingcong;ZHANG Yuan(Emergency Department,Foshan Fosun Chancheng Hospital,Foshan 528000,Guangdong,China;Electrophysiology Department,Foshan Fosun Chancheng Hospital,Foshan 528000,Guangdong,China)

机构地区：[1]佛山复星禅诚医院急诊科,广东佛山528000 [2]佛山复星禅诚医院电生理科,广东佛山528000

出　　处：《广州医科大学学报》2025年第1期20-24,共5页Academic Journal of Guangzhou Medical University

基　　金：佛山市自筹经费类科技计划项目(2320001009546)。

摘　　要：目的:探究曲克芦丁脑蛋白水解物联合尼麦角林对急性缺血性脑卒中(AIS)患者的影响。方法:选取2023年1月至2023年12月本院诊疗AIS患者160例,根据治疗方法不同分为对照组、观察组。其中予以尼麦角林+曲克芦丁脑蛋白水解物的80例为观察组,予以尼麦角林的80例为对照组。比较两组临床疗效、不良反应发生率、治疗前后脑血液流变学[大脑中动脉(MCA)的舒张末期血流速度(Vd)、收缩期峰值血流速度(Vp)、平均血流速度(Vm)]、氧化应激[超氧化物歧化酶(SOD)、晚期氧化蛋白产物(AOPP)、丙二醛(MDA)]及相关血清因子[神经生长因子(NGF)、神经元特异性烯醇化酶(NSE)、神经营养因子(NTF)]水平。结果:治疗后观察组脑血液流变学水平高于对照组(P<0.05);两组临床总有效率比较,差异显著(87.50%比75.00%,P<0.05);观察组治疗后SOD水平升高幅度大于对照组,AOPP、MDA水平降低幅度小于对照组(P<0.05);治疗后观察组NTF水平高于对照组,NSE、NGF水平低于对照组(P<0.05);两组不良反应发生率比较,无显著差异(16.25%比8.75%,P>0.05)。结论:曲克芦丁脑蛋白水解物联合尼麦角林治疗AIS疗效明显,可有效改善脑血液流变学,调节体内氧化应激反应,修复神经元,安全性较高。Objective:To investigate the effects of troxrutin brain protein hydrolysate combined with niergoline on patients with acute ischemic stroke(AIS).Method:160 patients with AIS were selected from January 2023 to December 2023,and divided into control group and observation group according to different treatment methods.Among them,80 cases receiving niergoline+troxrutin brain protein hydrolysate were observation group and 80 cases receiving niergoline were control group.The clinical efficacy,incidence of adverse reactions,cerebral hemorheology(end-diastolic blood flow velocity(Vd),peak systolic blood flow velocity(Vp),average blood flow velocity(Vm)),oxidative stress(superoxide dismutase(SOD),advanced oxidized protein product(AOPP),malondialdehyde(MDA))before and after treatment were compared between the two groups.And related serum factors(nerve growth factor(NGF),neuron-specific enolase(NSE),neurotrophic factor(NTF))levels.Result:After treatment,the level of cerebral hemorheology in observation group was higher than that in control group(P<0.05).The total clinical effective rate of the two groups was significantly different(87.50%vs 75.00%,P<0.05).After treatment,the increase of SOD level in observation group was greater than that in control group,and the decrease of AOPP and MDA levels was smaller than that in control group(P<0.05).After treatment,NTF levels in observation group were higher than those in control group,NSE and NGF levels were lower than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(16.25%vs 8.75%,P>0.05).Conclusion:Troxrutin brain protein hydrolysate combined with niergoline is effective in the treatment of AIS,which can effectively improve cerebral hemorheology,regulate oxidative stress response in vivo,repair neurons,and has high safety.

关 键 词：曲克芦丁脑蛋白水解物 尼麦角林 急性缺血性脑卒中 脑血液流变学 氧化应激 

分 类 号：R743.3[医药卫生—神经病学与精神病学]