An ionic liquid nanoparticles for dermal targeted delivery and effective anti-wrinkle treatment  

作　　者：Huixian Xu Qiaomei Huang Jingyao Gan De Bai Bo Yang Zhenyuan Wang Jichuan Zhang Chengyu Wu Jiaheng Zhang 

机构地区：[1]Sauvage Laboratory for Smart Materials,Harbin Institute of Technology,Shenzhen 518055,China [2]Department of Raw Material Reseach,Shenzhen Shinehigh Innovation Technology Co.,Ltd.,Shenzhen 518055,China [3]Department of Pharmaceutical Sciences and the Biointerfaces Institute,University of Michigan,Ann Arbor,MI 48109,USA [4]College of Pharmacy,Shenzhen Technology University,Shenzhen 518118,China

出　　处：《Journal of Dermatologic Science and Cosmetic Technology》2024年第4期16-25,共10页皮肤科学与化妆品技术期刊(英文)

基　　金：financially supported by the National Natural Science Foundation of China(nos.21905069,U21A20307);the Shenzhen Science and Technology Innovation Committee(nos.ZDSYS20190902093220279,KQTD20170809110344233,GXWD20201230155427003-20200821181245001,GXWD20201230155427003-20200821181809001,and ZX20200151);the Department of Science and Technology of Guangdong Province(no.2020A1515110879).

摘　　要：Background:Aging is a natural process that cannot be stopped but retarded.Hydroxypinacolone retinoate(HPR)is a potent anti-wrinkle agent,but with severe irritancy,low stability,and poor water solubility,making it hard to apply in cosmetics.Ionic liquid(IL),as a solvent,displayed improved transdermal efficiency.The role of nanoencapsulation technology in addressing the disadvantages of efficacy application is significant.Objective:Using a combination of ionic liquids and nano-encapsulation technology to obtain HPR-encapsulated ionic liquid nanoparticles(HPR IL-NPs)is an innovative formulation used as a serum,emulsion,and cream in cosmetics for effective anti-wrinkle.Methods:HPR IL-NPs were prepared using matrine coconut oil ionic liquid as a surfactant and permeation enhancer combined with high-pressure homogenization.Results:The average particle size in the obtained HPR IL-NPs was 92.8 nm.Applying the HPR IL-NPs increased the content of active substances in the skin by 3.6-fold compared to a traditional HPR-loaded cream.The chick chorioallantois membrane assay showed an RC50>100%,and repeated skin-irritation tests resulted in a mean value of 0.00 points per animal per day.The HPR IL-NPs showed continuous release for 24 h in vitro in the continuous release test.At the same time,the HPR IL-NPs significantly reduced irritation induced by HPR alone.The number and area of facial wrinkles decreased by 25.09%and 23.65%,respectively,after one week of application of liquid cream on volunteers.Conclusion:IL NPs can significantly improve transdermal absorption efficiency,reduce irritation,and demonstrate high anti-wrinkle efficiency.Supramolecular liquid cream is a promising product in cosmetics for skin care.

关 键 词：Liquid cream Ionic liquid Transdermal delivery LONG-ACTING ANTI-WRINKLE 

分 类 号：R944.9[医药卫生—药剂学]