LONG-ACTING

作品数：50被引量：86H指数：6
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相关领域：医药卫生更多>>
相关机构：广州医科大学北京大学清华大学更多>>
相关期刊：《Chinese Medical Journal》《World Journal of Diabetes》《Advances in Reproductive Sciences》《浙江省医学科学院学报》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金湖北省自然科学基金更多>>
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Safety,dosimetry,and efficacy of an optimized long-acting somatostatin analog for peptide receptor radionuclide therapy in metastatic neuroendocrine tumors:From preclinical testing to first-in-human study
《Acta Pharmaceutica Sinica B》2025年第2期707-721,共15页Wei Guo Xuejun Wen Yuhang Chen Tianzhi Zhao Jia Liu Yucen Tao Hao Fu Hongjian Wang Weizhi Xu Yizhen Pang Liang Zhao Jingxiong Huang Pengfei Xu Zhide Guo Weibing Miao Jingjing Zhang Xiaoyuan Chen Haojun Chen 
supported by the National Natural Science Foundation of China(No.82071961);Fujian Research and Training Grants for Young and Middle-aged Leaders in Healthcare,Key Scientific Research Program for Yong Scholars in Fujian(No.2021ZQNZD016,China);Fujian Natural Science Foundation for Distinguished Young Scholars(No.2022D005,China);Innovation of Science and Technology,Fujian Province(No.2021Y9134,China);National University of Singapore(No.NUHSRO/2020/133/Startup/08,NUHSRO/2023/008/NUSMed/TCE/LOA,NUHSRO/2021/034/TRP/09/Nanomedicine);National Medical Research Council(No.MOH-001388-00,MOH-001041,CG21APR1005,Singapore);Singapore Ministry of Education(No.MOE-000387-00,Singapore);National Research Foundation(No.NRF-000352-00,Singapore).
Peptide receptor radionuclide therapy(PRRT)with radiolabeled SSTR2 agonists is a treatment option that is highly effective in controlling metastatic and progressive neuroendocrine tumors(NETs).Previous studies have sh...
关键词：Radiolabeled somatostatin analog Neuroendocrine tumor Evans blue ^(177)Lu-LNC1010 Peptide receptor radionuclide therapy First-in-human dose escalation study 
An ionic liquid nanoparticles for dermal targeted delivery and effective anti-wrinkle treatment
《Journal of Dermatologic Science and Cosmetic Technology》2024年第4期16-25,共10页Huixian Xu Qiaomei Huang Jingyao Gan De Bai Bo Yang Zhenyuan Wang Jichuan Zhang Chengyu Wu Jiaheng Zhang 
financially supported by the National Natural Science Foundation of China(nos.21905069,U21A20307);the Shenzhen Science and Technology Innovation Committee(nos.ZDSYS20190902093220279,KQTD20170809110344233,GXWD20201230155427003-20200821181245001,GXWD20201230155427003-20200821181809001,and ZX20200151);the Department of Science and Technology of Guangdong Province(no.2020A1515110879).
Background:Aging is a natural process that cannot be stopped but retarded.Hydroxypinacolone retinoate(HPR)is a potent anti-wrinkle agent,but with severe irritancy,low stability,and poor water solubility,making it hard...
关键词：Liquid cream Ionic liquid Transdermal delivery LONG-ACTING ANTI-WRINKLE 
Sunlenca■(Lenacapavir):A first-in-class,long-acting HIV-1 capsid inhibitor for treating highly multidrug-resistant HIV-1 infection
《Acta Pharmaceutica Sinica B》2024年第12期5512-5514,共3页Chunhua Ma Junbiao Chang Bin Yu 
support from the National Natural Science Foundation of China(Nos.22277110 and 82003585)and Tianjian Laboratory of Advanced Biomedical Sciences.
Lenacapavir,also known as GS-6207,under the brand name Sunlenca,was developed by Gilead Sciences Inc.It has been approved in the EU,Canada,and US for use alongside other antiretrovirals in adults with multidrug-resist...
关键词：Lenacapavir Capsid inhibitor HIV-1 infection HIV prevention Multidrug resistance Antiretroviral medication 
Effect of long-acting polyethylene glycol recombinant human growth hormone dosages in pediatric practice:A pooled analysis of two phase IV randomized controlled trials
《Chinese Medical Journal》2024年第17期2125-2127,共3页Ling Hou Xuefeng Chen Hongwei Du Jianping Zhang Xinran Cheng Jiayan Pan Hui Pan Wei Liao Xiaoping Luo Junfen Fu on Behalf of the 045 Study Group 
To the Editor:Growth hormone deficiency(GHD)impairs growth and development,affecting approximately 1 in 4000 children worldwide.[1]Recombinant human growth hormone(rhGH)has been standard practice since 1985.[2]However...
关键词：DOSAGE analysis GLYCOL 
Accelerated infected wound healing by probiotic-based living microneedles with long-acting antibacterial effect被引量：2
《Bioactive Materials》2024年第8期292-304,共13页Yinli Jin Yun Lu Xue Jiang Min Wang Yaqi Yuan Yongnian Zeng Liang Guo Wei Li 
support from the National Natural Science Foundation of China(NSFC,No.82373798,No.52103182);Youth Interdisciplinary Special Fund of Zhongnan Hospital of Wuhan University(Grant No.ZNQNJC2023002);Young Talents Project of Hubei Province Administration of Traditional Chinese Medicine(No.ZY2023Q014).
Delays in infected wound healing are usually a result of bacterial infection and local inflammation,which imposes a significant and often underappreciated burden on patients and society.Current therapies for chronic w...
关键词：MICRONEEDLES Infected wound healing Probiotic Transdermal delivery LONG-ACTING 
Outcomes of long-acting injectable antipsychotics use in pregnancy:A literature review
《World Journal of Psychiatry》2024年第4期582-599,共18页Ana V Pejčić Srdjan M Stefanović MilošN Milosavljević Vladimir S Janjić Marko M Folić Nevena D Folić Jovana Z Milosavljević 
BACKGROUND Women with a history of serious psychotic disorders are at increased risk of disease relapse during pregnancy.Long-acting injectable(LAI)antipsychotics have been widely used to improve adherence and prevent...
关键词：Antipsychotic agents Long-acting injectable PREGNANCY OUTCOME Review 
Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis
《Acta Pharmaceutica Sinica B》2024年第3期1283-1301,共19页Qian Zhao Jiale Dong Han Liu Hui Chen Huan Yu Shuyin Ye Shuangjin Yu Yu Li Longhui Qiu Nazi Song Hongjiao Xu Qi Liu Zhiteng Luo Yuyi Li Rui Wang Guodong Chen Xianxing Jiang 
financial support from the National Natural Science Foundation of China(No.82273761 and No.81871257);the Medical Innovation and Development Project of Lanzhou University(lzuyxcx-2022-156,China);the Undergraduate Teaching Quality Engineering Project of Sun Yat-sen University[2021]93;the Guangdong Provincial Key Laboratory of Construction Foundation(2023B1212060022,China)。
The role of co-agonists of glucagon-like peptide-1 receptor(GLP-1R)and glucagon receptor(GCGR)in chronic kidney disease(CKD)remains unclear.Herein we found that GLP-1R and GCGR expression levels were lower in the kidn...
关键词：GLP-1 receptor Glucagon receptor Chronic kidney disease Diabetic nephropathy Kidney fibrosis Dual-agonism 
Factors Influencing the Choice between IUD and Implant among Long-Acting Reversible Contraceptive (LARCs) Users in Burkina Faso
《Advances in Reproductive Sciences》2023年第4期73-85,共13页Lonkila Moussa Zan Georges Guiella 
Background: Long-acting and reversible contraceptive methods hold great potential as solutions to address the unmet need for contraception and the significant discontinuation rates, especially in sub-Saharan Africa. A...
关键词：Modern Contraceptives Long-Acting Reversible Contraceptives (LARCs) CONTRACEPTION Family Planning Autonomy Burkina Faso 
Effects of different doses of long-acting growth hormone in treating children with growth hormone deficiency被引量：1
《World Journal of Clinical Cases》2023年第28期6715-6724,共10页Wei Xia Ting Wang Jia-Yan Pan 
BACKGROUND With the improvement of economy and living standards,the attention paid to short stature in children has been increasingly highlighted.Numerous causes can lead to short stature in children,among which growt...
关键词：CHILDREN Growth hormone deficiency Polyethylene glycol recombinant human growth hormone Different doses Bone age 
Biodegradable implants based on photo-cross-linked aliphatic polycarbonates for long-acting contraception
《Journal of Materials Science & Technology》2023年第25期129-141,共13页Zhipeng Hou Wei Xu Siwen Chen Jing Guo Peng Li Jianshe Hu Liqun Yang Jing Chen 
sponsored by the Natural Science Foundation of Liaoning Province(Nos.2022-YGJC-69,2021-BS-110);the support program for excellent young scholars of China Medical University.
In this study,a new class of biodegradable contraceptive implants was prepared via the UV irradiation molding method,among which,progestin levonorgestrel(LNG)was used as a model drug.Photo-cross-linked aliphatic polyc...
关键词：Aliphatic polycarbonates Photo-cross-linked LEVONORGESTREL Contraceptive implants Anti-fertility effects SUSTAINED-RELEASE 
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